1. To collect marine sponges from tropical habitats in Papua New Guinea, the Galapagos Islands and Sri Lanka, and from cold water habitats in Canada and Norway. It is anticipated that in excess of 800 species of sponges will be collected over the duration of the granting period. 2. To prepare extracts of the marine sponges for evaluation in anticancer screens carried out by American Cyanamid. 3.To isolate pure active sponge metabolites using bio-assay guided fractionation and to elucidate their chemical structures. 4. To assist Lederle Laboratory scientists in isolating microorganisms in the field from sponge samples collected by Andersen group divers. 5. To use bio-assay guided fractionation to isolate pure active microorganism metabolites from fermentation broth extracts generated by Lederle Laboratories and to elucidate their chemical structures. 6. To isolate sufficient quantities of promising new lead compounds from sponges or microbial broths for in vivo evaluation in animal models by Kramer's group at Lederle Laboratories.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19CA067786-03
Application #
6237583
Study Section
Project Start
1997-09-01
Project End
1998-08-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
3
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Utah
Department
Type
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Dalisay, Doralyn S; Williams, David E; Wang, Xiao Ling et al. (2013) Marine sediment-derived Streptomyces bacteria from British Columbia, Canada are a promising microbiota resource for the discovery of antimicrobial natural products. PLoS One 8:e77078
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Williams, David E; Loganzo, Frank; Whitney, Lauren et al. (2011) Depsides isolated from the Sri Lankan lichen Parmotrema sp. exhibit selective Plk1 inhibitory activity. Pharm Biol 49:296-301
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