) This proposed grant renewal builds on the significant achievements in the area of microbial bioprospecting and drug discovery of our current NCDDG award CA67786. We wish to continue our progress on the initially proposed objectives and to extend this work to include new goals. 1) To continue with the isolation and taxonomic characterization of unusual microbial biodiversity from diverse marine environments, including those living in close association with marine plants and animals. 2) To continue to use the MIDI(TM) system and employ the newest techniques of ribotyping for taxonomic identification of the isolated microorganisms. 3) To continue the fermentation and processing of microbial cultures to provide extract samples for biological evaluation in various Oncology screening systems. Provide these same fermentation and processing operations for the microbial cultures isolated and provided to the W- AR Natural Products Microbiology. 4) To provide scale-up fermentation and processing support to generate material for isolation and chemical characterization, expanded biological profiling, and in vivo testing.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19CA067786-07
Application #
6483398
Study Section
Project Start
2001-08-01
Project End
2002-04-30
Budget Start
Budget End
Support Year
7
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of Utah
Department
Type
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Dalisay, Doralyn S; Williams, David E; Wang, Xiao Ling et al. (2013) Marine sediment-derived Streptomyces bacteria from British Columbia, Canada are a promising microbiota resource for the discovery of antimicrobial natural products. PLoS One 8:e77078
Prasad, Pritesh; Aalbersberg, William; Feussner, Klaus-D et al. (2011) Papuamides E and F, Cytotoxic Depsipeptides from the Marine Sponge Melophlus sp. Tetrahedron 67:8529-8531
Williams, David E; Loganzo, Frank; Whitney, Lauren et al. (2011) Depsides isolated from the Sri Lankan lichen Parmotrema sp. exhibit selective Plk1 inhibitory activity. Pharm Biol 49:296-301
Janso, Jeffrey E; Carter, Guy T (2010) Biosynthetic potential of phylogenetically unique endophytic actinomycetes from tropical plants. Appl Environ Microbiol 76:4377-86
Williams, David E; Yu, Ker; Behrisch, Hans W et al. (2009) Rolloamides A and B, cytotoxic cyclic heptapeptides isolated from the Caribbean marine sponge Eurypon laughlini. J Nat Prod 72:1253-7
Williams, David E; Hollander, Irwin; Feldberg, Larry et al. (2009) Scalarane-based sesterterpenoid RCE-protease inhibitors isolated from the Indonesian marine sponge Carteriospongia foliascens. J Nat Prod 72:1106-9
Whitson, Emily L; Bugni, Tim S; Chockalingam, Priya S et al. (2009) Fibrosterol sulfates from the Philippine sponge Lissodendoryx (Acanthodoryx) fibrosa: sterol dimers that inhibit PKCzeta. J Org Chem 74:5902-8
Roll, Deborah M; Barbieri, Laurel R; Bigelis, Ramunas et al. (2009) The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144. J Nat Prod 72:1944-8
Whitson, Emily L; Ratnayake, Anokha S; Bugni, Tim S et al. (2009) Isolation, structure elucidation, and synthesis of eudistomides A and B, lipopeptides from a Fijian ascidian Eudistoma sp. J Org Chem 74:1156-62
Bugni, Tim S; Harper, Mary Kay; McCulloch, Malcolm W B et al. (2008) Fractionated marine invertebrate extract libraries for drug discovery. Molecules 13:1372-83

Showing the most recent 10 out of 38 publications