Project 3: Epidemiological and Clinical Translational Studies Post Genome-Wide Association (GWAS) Project Leader: Rosalind Eeles Project Summary: The main focus of Project 3 is establishing a transdisciplinary collaborative network comprised of clinical scientists, epidemiologists, geneticists, and biostatisticians focusing on the transition from 'bench-side'research to 'bed-side'care. The CEC (Clinical ELLIPSE Consortium) will harmonize genetic, clinical, and environmental data from existing consortia, with over 35,000 prostate cancer cases, to evaluate gene, genegene, and gene-environmental effects on prostate cancer risk, including aggressive disease, recurrence, and mortality. The highly integrated ELLIPSE projects will facilitate the most up to date genetic evaluation by working closely with Project 1, identifying novel genetic candidates, and Project 2, providing biological insights on function. The assessment of genetic and environmental interactions will be evaluated for inclusion into a risk score as well as potentially providing directional input for Projects 1 and 2. All risk evaluations will be assessed in European, African American, and Japanese populations. Finally, this initial stage will provide the necessary guidance in developing useful and powerful risk prediction models for prostate cancer risk, including screening, outcome and treatment effects. These risk prediction models may have an immediate public health impact by providing clinicians with the necessary tools to improve clinical-decision making.

Public Health Relevance

The main focus of this project is to establish a transdisciplinary network of highly innovative scientists investigating the impact of genetic, environmental, and effect modifiers (ie gene-gene and gene-environment) on prostate cancer risk in a multiethnic sample. In particular, this project will initiate the process the of going from the 'bench-side'to the 'bed-side'by developing risk prediction models needed in prostate cancer prediction, screening, progression, and treatments.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19CA148537-01
Application #
7933390
Study Section
Special Emphasis Panel (ZCA1-SRLB-4 (J1))
Project Start
2010-04-01
Project End
2014-03-31
Budget Start
2010-04-01
Budget End
2011-06-30
Support Year
1
Fiscal Year
2010
Total Cost
$132,643
Indirect Cost
Name
University of Southern California
Department
Type
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Sud, Amit; Thomsen, Hauke; Orlando, Giulia et al. (2018) Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma. Blood 132:2040-2052
Zuber, Verena; Jönsson, Erik G; Frei, Oleksandr et al. (2018) Identification of shared genetic variants between schizophrenia and lung cancer. Sci Rep 8:674
Park, Sungshim L; Cheng, Iona; Haiman, Christopher A (2018) Genome-Wide Association Studies of Cancer in Diverse Populations. Cancer Epidemiol Biomarkers Prev 27:405-417
O'Mara, Tracy A; Glubb, Dylan M; Amant, Frederic et al. (2018) Identification of nine new susceptibility loci for endometrial cancer. Nat Commun 9:3166
Rebbeck, Timothy R (see original citation for additional authors) (2018) Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations. Hum Mutat 39:593-620
Went, Molly; Sud, Amit; Försti, Asta et al. (2018) Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma. Nat Commun 9:3707
FitzGerald, L M; Zhao, S; Leonardson, A et al. (2018) Germline variants in IL4, MGMT and AKT1 are associated with prostate cancer-specific mortality: An analysis of 12,082 prostate cancer cases. Prostate Cancer Prostatic Dis 21:228-237
Matejcic, Marco; Saunders, Edward J; Dadaev, Tokhir et al. (2018) Germline variation at 8q24 and prostate cancer risk in men of European ancestry. Nat Commun 9:4616
Painter, Jodie N; O'Mara, Tracy A; Morris, Andrew P et al. (2018) Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses. Cancer Med 7:1978-1987
Loveday, Chey; Litchfield, Kevin; Levy, Max et al. (2018) Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer. Oncotarget 9:12630-12638

Showing the most recent 10 out of 154 publications