The administrative core will function primarily to serve the budgetary, reporting and organizational aspects ofthe CDDG. One of the main functions of the administrative core will be to organize weekly, monthly and yearlymeetings and phone conferences with the assembled members of the CDDG. Mr. Evans will workclosely with Dr. Roth and the various investigators to schedule weekly phone conferences and monthlyface-to-face meetings with the Duke and UNC investigators. The Wyeth group will participate in theweekly and monthly meetings via phone conference. Yearly meetings will be scheduled for the Pi's ofthe various projects and cores at either the ACNP meeting or the Society for Neurosciences AnnualMeetings. We will set aside half a day during either of those two meetings for brief project reports anddiscussions regarding the overall direction.* Mr. Evans will help to coordinate the collection and collation of the yearly progress reports which arerequired as part of the reporting to NIMH.* Mr. Evans will also help to coordinate the subcontracting and budgetary matters related to travel for thepost-doctoral fellows who will visit Wyeth to gain hands-on experience with rodent models ofantipsychotic drug actions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19MH082441-01
Application #
7451344
Study Section
Special Emphasis Panel (ZMH1-ERB-C (06))
Project Start
2007-09-28
Project End
2012-04-30
Budget Start
2007-09-28
Budget End
2008-04-30
Support Year
1
Fiscal Year
2007
Total Cost
$57,435
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Che, Tao; Majumdar, Susruta; Zaidi, Saheem A et al. (2018) Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor. Cell 172:55-67.e15
Wang, Sheng; Che, Tao; Levit, Anat et al. (2018) Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone. Nature 555:269-273
Rose, Samuel J; Pack, Thomas F; Peterson, Sean M et al. (2018) Engineered D2R Variants Reveal the Balanced and Biased Contributions of G-Protein and ?-Arrestin to Dopamine-Dependent Functions. Neuropsychopharmacology 43:1164-1173
McCorvy, John D; Butler, Kyle V; Kelly, Brendan et al. (2018) Structure-inspired design of ?-arrestin-biased ligands for aminergic GPCRs. Nat Chem Biol 14:126-134
McCorvy, John D; Wacker, Daniel; Wang, Sheng et al. (2018) Structural determinants of 5-HT2B receptor activation and biased agonism. Nat Struct Mol Biol 25:787-796
Peng, Yao; McCorvy, John D; Harpsøe, Kasper et al. (2018) 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. Cell 172:719-730.e14
Wang, Sheng; Wacker, Daniel; Levit, Anat et al. (2017) D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science 358:381-386
Wacker, Daniel; Wang, Sheng; McCorvy, John D et al. (2017) Crystal Structure of an LSD-Bound Human Serotonin Receptor. Cell 168:377-389.e12
Wacker, Daniel; Stevens, Raymond C; Roth, Bryan L (2017) How Ligands Illuminate GPCR Molecular Pharmacology. Cell 170:414-427
Arnsten, Amy F T; Girgis, Ragy R; Gray, David L et al. (2017) Novel Dopamine Therapeutics for Cognitive Deficits in Schizophrenia. Biol Psychiatry 81:67-77

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