The Central Operations Core (COC) at Georgia Institute of Technology (GIT) will act as the central repository for all materials and related data associated with the biological samples and pharmacological testing that will be conducted for this ICBG program. Collection, processing, and assay data will be managed using the Natural Products Information System (NAPIS) database. The COC will manage the existing library of 8000+ extracts and continue to acquire new extracts via collections, while efficiently distributing these to collaborators for screening in assays relevant to the U.S., low and middle-income countries (LMICs), and the island nations of the South Pacific. Assays will target the following disease areas: i) infectious disease, ii) neglected tropical diseases (NTDs) iii) cancer, and iv) neurodegenerative, CNS, and psychoactive disorders. Hit prioritization will be evaluated via potency, bioactivity spectrum, cytotoxicity and chemical novelty based on LC-MS de-replication, genomic and taxonomic novelty emphasizing understudied species and ecotypes, and chemical ecology data. Our industrial partners Cubist Pharmaceuticals and Eisai Inc. will also assist with prioritization based on issues of efficacy, mode of action, and medicinal chemistry properties. The COC will also coordinate legal agreements, contracts, and permits required for domestic and international research activities and oversee the safe transfer of extracts, fractions or bulk samples from the CDDC in Fiji to the COC in Atlanta, as well as coordinate collecting trips to Fiji and the Solomon Islands in collaboration with the CDDC. The COC has considerable experience with the above issues. To date, its personnel have organized 8,496 extracts that have been screened in a variety of cell and molecular target-based assays to produce 221,805 assay results that have thus far lead to the identification of 121 bioactive natural products, including 48 novel compounds from marine algae, 7 from marine-invertebrates, and 33 from microbes.
| Beatty, Deanna S; Clements, Cody S; Stewart, Frank J et al. (2018) Intergenerational effects of macroalgae on a reef coral: major declines in larval survival but subtle changes in microbiomes. Mar Ecol Prog Ser 589:97-114 |
| Chhetri, Bhuwan Khatri; Lavoie, Serge; Sweeney-Jones, Anne Marie et al. (2018) Recent trends in the structural revision of natural products. Nat Prod Rep 35:514-531 |
| Clements, Cody S; Rasher, Douglas B; Hoey, Andrew S et al. (2018) Spatial and temporal limits of coral-macroalgal competition: the negative impacts of macroalgal density, proximity, and history of contact. Mar Ecol Prog Ser 586:11-20 |
| Clements, Cody S; Hay, Mark E (2018) Overlooked coral predators suppress foundation species as reefs degrade. Ecol Appl 28:1673-1682 |
| Machado, Henrique; Tuttle, Robert N; Jensen, Paul R (2017) Omics-based natural product discovery and the lexicon of genome mining. Curr Opin Microbiol 39:136-142 |
| Clements, Cody S; Hay, Mark E (2017) Size matters: Predator outbreaks threaten foundation species in small Marine Protected Areas. PLoS One 12:e0171569 |
| Letzel, Anne-Catrin; Li, Jing; Amos, Gregory C A et al. (2017) Genomic insights into specialized metabolism in the marine actinomycete Salinispora. Environ Microbiol 19:3660-3673 |
| Lavoie, Serge; Brumley, David; Alexander, Troy S et al. (2017) Iodinated Meroditerpenes from a Red Alga Callophycus sp. J Org Chem 82:4160-4169 |
| Steneck, Robert S; Bellwood, David R; Hay, Mark E (2017) Herbivory in the marine realm. Curr Biol 27:R484-R489 |
| Demko, Alyssa M; Amsler, Charles D; Hay, Mark E et al. (2017) Declines in plant palatability from polar to tropical latitudes depend on herbivore and plant identity. Ecology 98:2312-2321 |
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