Minor dysmorphologies of the face in the neonate are well accepted indicators of increased risk for impaired functions in central nervous system or for major malformation. About one-fourth of neonates at Howard University Hospital have been exposed to potential teratogens. Some of these yield developmental delays and minor face dysmorphologies. Clinical decisions about the letter typically are subject to high ovservor variability. There is need for a sensitive and objective method by which to decide which neonates are at risk for developmental delays. The goals of this study are to establish quantitative norms for 23 selected morphometric landmarks on the faces of African American neonates, and to test for potential shifts in such lnadmarks in response to alcohol and other teratogens to which these infants were exposed. Face photographs will be obtained on 1500 - 1700 unselected neonates and prenatal medical and teratogen histories recorded through screening interviews of their mothers. Measurements of distances among selected pairs of the 23 landmarks on the photographs will be analyzed by triangles defined by sets of three landmarks. The X, Y coordinates of the vertex landmark of each triangle will be tested by an F statistic for clustering according to each of the teratogen unexposed and exposed classes of infants.

Project Start
1997-09-30
Project End
1998-08-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Howard University
Department
Type
DUNS #
056282296
City
Washington
State
DC
Country
United States
Zip Code
20059
Cain, Gloria E; Kalu, Nnenna; Kwagyan, John et al. (2016) Beliefs and Preferences for Medical Research Among African-Americans. J Racial Ethn Health Disparities 3:74-82
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Marshall, Vanessa J; Kalu, Nnenna; Kwagyan, John et al. (2013) Alcohol dependence and health care utilization in African Americans. J Natl Med Assoc 105:42-9
Marshall, Vanessa J; Kalu, Nnenna; Kwagyan, John et al. (2012) Perceptions about genetic testing for the susceptibility to alcohol dependence and other multifactorial diseases. Genet Test Mol Biomarkers 16:476-81
Marshall, Vanessa J; McLaurin-Jones, TyWanda L; Kalu, Nnenna et al. (2012) Screening, brief intervention, and referral to treatment: public health training for primary care. Am J Public Health 102:e30-6
Taylor, Robert E; Raysor, Byron R; Kwagyan, John et al. (2008) Alterations in ethyl alcohol pharmacokinetics during oral consumption of malt liquor beverages in African Americans. Alcohol Clin Exp Res 32:2074-80
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Sobrian, Sonya K; Jones, Barbara L; Varghese, Shiny et al. (2003) Behavioral response profiles following drug challenge with dopamine receptor subtype agonists and antagonists in developing rat. Neurotoxicol Teratol 25:311-28

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