Abstract

The CIFASD Informatics Core provides a research data resource to be used by investigators to explore the relationships of face, brain, and behavior to improve the diagnosis of FAS and work towards therapies for alcohol exposed children. The Informatics Core has the following specific aims for the next five years:
Aim 1 : Continued cyber infrastructure support. The Informatics Core will consult and collaborate with CIFASD clinical projects, cores, and developmental projects to support the existing data submission to the CIFASD Central Repository, manage those data, and make those data available for use to accomplish CIFASD goals.
Aim 2 : Collection of additional data sets. The Informatics Core will securely bring new data sets into the CIFASD Central Repository for cross-study and cross-modality data analysis amongst CIFASD projects.
Aim 3 : Support of affiliated projects. The Informatics Core will develop technical solutions that will allow the comparison of data between CIFASD and affiliated projects. The Informatics core will use the following methods to support the goals of this project and CIFASD: The ongoing management of standardized data in the CIFASD Central Repository will provide core consortium resources including;data input and bulk upload tools, a data dictionary to standardize terms across studies, a cross query tool so that data from multiple studies can be integrated for synthetic studies, and data browsing tools that enable investigators to ensure data quality. Expert consultation will support the input, export, and integration of data in the Central Repository to lower the barrier of use for investigators and improve data quality of synthetic studies. This consultation will also regularly report on data in the Central Repository to track consortium progress goals. Expert software engineering will provide new input tools and modify existing tools to support the changing needs of CIFASD projects as well as new research projects that are added as part of the third Phase of the CIFASD program.

Public Health Relevance

The goal of the CIFASD Informatics Core is to support research on the relationships efface, brain, and behavior in order to improve the diagnosis of Fetal Alcohol Spectrum Disorders and work towards therapies for alcohol exposed children. By providing a central, standardized data resource for CIFASD, the Informatics Core will provide a means by which comprehensive diagnostics and therapies can be developed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
2U24AA014818-09
Application #
8401660
Study Section
Special Emphasis Panel (ZAA1-CC (02))
Program Officer
Dunty, Jr, William
Project Start
2003-09-30
Project End
2017-05-31
Budget Start
2012-08-10
Budget End
2013-05-31
Support Year
9
Fiscal Year
2012
Total Cost
$160,563
Indirect Cost
$57,638

  Institution

Name
Indiana University Bloomington
Department
Miscellaneous
Type
Schools of Education
DUNS #
006046700
City
Bloomington
State
IN
Country
United States
Zip Code
47401

  Publications

Hendrickson, Timothy J; Mueller, Bryon A; Sowell, Elizabeth R et al. (2018) Two-year cortical trajectories are abnormal in children and adolescents with prenatal alcohol exposure. Dev Cogn Neurosci 30:123-133
Wozniak, Jeffrey R; Mueller, Bryon A; Mattson, Sarah N et al. (2017) Functional connectivity abnormalities and associated cognitive deficits in fetal alcohol Spectrum disorders (FASD). Brain Imaging Behav 11:1432-1445
Hendrickson, Timothy J; Mueller, Bryon A; Sowell, Elizabeth R et al. (2017) Cortical gyrification is abnormal in children with prenatal alcohol exposure. Neuroimage Clin 15:391-400
Glass, Leila; Graham, Diana M; Deweese, Benjamin N et al. (2014) Correspondence of parent report and laboratory measures of inattention and hyperactivity in children with heavy prenatal alcohol exposure. Neurotoxicol Teratol 42:43-50
Nguyen, Tanya T; Glass, Leila; Coles, Claire D et al. (2014) The clinical utility and specificity of parent report of executive function among children with prenatal alcohol exposure. J Int Neuropsychol Soc 20:704-16
Ware, Ashley L; Glass, Leila; Crocker, Nicole et al. (2014) Effects of prenatal alcohol exposure and attention-deficit/hyperactivity disorder on adaptive functioning. Alcohol Clin Exp Res 38:1439-47
Graham, Diana M; Crocker, Nicole; Deweese, Benjamin N et al. (2013) Prenatal alcohol exposure, attention-deficit/hyperactivity disorder, and sluggish cognitive tempo. Alcohol Clin Exp Res 37 Suppl 1:E338-46
Mattson, Sarah N; Roesch, Scott C; Glass, Leila et al. (2013) Further development of a neurobehavioral profile of fetal alcohol spectrum disorders. Alcohol Clin Exp Res 37:517-28
Ware, Ashley L; O'Brien, Jessica W; Crocker, Nicole et al. (2013) The effects of prenatal alcohol exposure and attention-deficit/hyperactivity disorder on psychopathology and behavior. Alcohol Clin Exp Res 37:507-16
Glass, Leila; Ware, Ashley L; Crocker, Nicole et al. (2013) Neuropsychological deficits associated with heavy prenatal alcohol exposure are not exacerbated by ADHD. Neuropsychology 27:713-24

Showing the most recent 10 out of 14 publications