Abstract

The main objective of the Metabolism and Endocrinology Core is to provide the expertise, technical resources, and instrumentation necessary to characterize perturbations in metabolism in murine models potentially useful for understanding diabetes, its complications, obesity, and related metabolic disorders. The core will conduct in vivo and in vitro metabolic procedures and offer an extensive list of assays of metabolic substrates, endocrine hormones, and indices of renal function, inflammation and oxidative stress. In addition, the Metabolism and Endocrinology Core will provide assay management services for the analysis of samples generated by all cores.

Public Health Relevance

Mouse models of diabetes, diabetic complications, obesity and other related disorders have been invaluable for elucidating the disease potential, pathogenesis and treatment of these conditions in the human population. The Metabolism and Endocrinology Core will conduct procedures and analyses on mouse lines submitted to the MMPC-UCD in order to identify potential mouse models of human disease for study.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24DK092993-03
Application #
8517707
Study Section
Special Emphasis Panel (ZDK1-GRB-S)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
3
Fiscal Year
2013
Total Cost
$163,241
Indirect Cost
$43,211

  Institution

Name
University of California Davis
Department
Type
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Majtan, Tomas; Jones Jr, Wendell; Krijt, Jakub et al. (2018) Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria. Mol Ther 26:834-844
Yokoyama, Amy S; Dunaway, Keith; Rutkowsky, Jennifer et al. (2018) Chronic consumption of a western diet modifies the DNA methylation profile in the frontal cortex of mice. Food Funct 9:1187-1198
Rutkowsky, Jennifer M; Lee, Linda L; Puchowicz, Michelle et al. (2018) Reduced cognitive function, increased blood-brain-barrier transport and inflammatory responses, and altered brain metabolites in LDLr -/-and C57BL/6 mice fed a western diet. PLoS One 13:e0191909
Cheng, Yingduan; Yuan, Quan; Vergnes, Laurent et al. (2018) KDM4B protects against obesity and metabolic dysfunction. Proc Natl Acad Sci U S A 115:E5566-E5575
Rozman, Jan; Rathkolb, Birgit; Oestereicher, Manuela A et al. (2018) Identification of genetic elements in metabolism by high-throughput mouse phenotyping. Nat Commun 9:288
Hsu, Ming-Fo; Bettaieb, Ahmed; Ito, Yoshihiro et al. (2017) Protein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuria. Sci Rep 7:461
McGavigan, Anne K; Garibay, Darline; Henseler, Zachariah M et al. (2017) TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice. Gut 66:226-234
Ito, Yoshihiro; Hsu, Ming-Fo; Bettaieb, Ahmed et al. (2017) Protein tyrosine phosphatase 1B deficiency in podocytes mitigates hyperglycemia-induced renal injury. Metabolism 76:56-69
López-Yoldi, Miguel; Stanhope, Kimber L; Garaulet, Marta et al. (2017) Role of cardiotrophin-1 in the regulation of metabolic circadian rhythms and adipose core clock genes in mice and characterization of 24-h circulating CT-1 profiles in normal-weight and overweight/obese subjects. FASEB J 31:1639-1649
Jung, Chris J; Zhang, Junli; Trenchard, Elizabeth et al. (2017) Efficient gene targeting in mouse zygotes mediated by CRISPR/Cas9-protein. Transgenic Res 26:263-277

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