This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by the applicant): The overarching goal of the FBIRN is to develop technology and methods to conduct multisite functional imaging studies, and to produce a knowledge base that would not otherwise be available through single-site imaging studies. The technology includes the development and refinement of multi-site, functional imaging protocols using robust cognitive tasks; the development and refinement of algorithms to reduce inter-site variability; the use of federated, distributed databases and storage; flexible and robust image processing software integrated with these databases and storage infrastructure; tools for data querying across the distributed databases to extract subsets of data from multiple sources; and the development of both classical statistical and data mining methods to reveal the patterns of imaging, clinical, and behavioral data which differentiate important population clusters. To meet this goal, the FBIRN will develop the capacity to conduct a multi-center functional imaging study in a focused group of subjects with a neuropsychiatric disorder, patients with schizophrenia. The lessons learned, the statistical methods developed, and the informatics structure constructed will be generalizable and applicable to a wide variety of clinical investigations. The ability to integrate subsets of clinical, functional imaging, and behavioral datasets from disparate sites to form novel datasets will be assessed in a phased series of developments and optimizations. The overall goal of this proposal is to develop tools to make multi-site fMRI studies a common research practice. Completion of this goal enables researchers to investigate the pathophysiology of complex diseases more thoroughly, through the increased power of large-scale, collaborative neuroimaging studies. When completed, researchers in different fields and physical locations will be able to draw on a common set of tools and database systems not possible at a single site.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
1U24RR021992-01A1
Application #
7373398
Study Section
Special Emphasis Panel (ZRR1-BT-7 (01))
Project Start
2006-02-08
Project End
2006-11-30
Budget Start
2006-02-08
Budget End
2006-11-30
Support Year
1
Fiscal Year
2006
Total Cost
$2,334,888
Indirect Cost
Name
University of California Irvine
Department
Psychiatry
Type
Schools of Medicine
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Lavigne, Katie M; Woodward, Todd S (2018) Hallucination- and speech-specific hypercoupling in frontotemporal auditory and language networks in schizophrenia using combined task-based fMRI data: An fBIRN study. Hum Brain Mapp 39:1582-1595
Nakahara, Soichiro; Medland, Sarah; Turner, Jessica A et al. (2018) Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia. Schizophr Res 201:393-399
Hare, Stephanie M; Law, Alicia S; Ford, Judith M et al. (2018) Disrupted network cross talk, hippocampal dysfunction and hallucinations in schizophrenia. Schizophr Res 199:226-234
Kong, Xiang-Zhen; Mathias, Samuel R; Guadalupe, Tulio et al. (2018) Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium. Proc Natl Acad Sci U S A 115:E5154-E5163
van Erp, Theo G M; Walton, Esther; Hibar, Derrek P et al. (2018) Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. Biol Psychiatry 84:644-654
Potvin, Olivier; Dieumegarde, Louis; Duchesne, Simon et al. (2017) Freesurfer cortical normative data for adults using Desikan-Killiany-Tourville and ex vivo protocols. Neuroimage 156:43-64
Walton, E; Hibar, D P; van Erp, T G M et al. (2017) Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium. Acta Psychiatr Scand 135:439-447
Potvin, Olivier; Dieumegarde, Louis; Duchesne, Simon et al. (2017) Normative morphometric data for cerebral cortical areas over the lifetime of the adult human brain. Neuroimage 156:315-339
Gupta, Cota Navin; Castro, Eduardo; Rachkonda, Srinivas et al. (2017) Biclustered Independent Component Analysis for Complex Biomarker and Subtype Identification from Structural Magnetic Resonance Images in Schizophrenia. Front Psychiatry 8:179
Doran, Eric; Keator, David; Head, Elizabeth et al. (2017) Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer's Disease: The Role of APP. J Alzheimers Dis 56:459-470

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