This proposal for a TB and TB/HIV Training Program is submitted under Phase II """"""""International, Clinical, Operational, and Health Services Research Training Awards for AIDS and Tuberculosis"""""""" (Comprehensive ICOHRTA AIDS/TB). The purpose of this application is to create a training program that will allow investigators from Brazil to obtain research training experiences in operational and health services investigation, including epidemiology, surveillance, clinical trials, diagnostics, health economics, systems management, research ethics and other pertinent disciplines that will strengthen the overall tuberculosis research capacity in Brazil. Needs assessments have identified substantial shortcomings in research capacity in TB and TB/HIV in Brazil, and this application specifically targets a number of areas where improved capabilities could result in a strengthening of health services and improvements in human health. The ICOHRTA training program will draw upon the considerable strengths of the Johns Hopkins University and the Federal University of Rio de Janeiro, and build upon a 15-year partnership in carrying out TB and HIV research and training. The program includes partnerships with the Weill Medical College of Cornell University and the University of California, Berkeley, both of which have strong track records in supporting research training in Brazil and which offer unique training opportunities that strengthen the program. In Brazil, partner institutions include the Federal University of Espirito Santo, the Adolpho Lutz Institute and the Municipal Health Department of Rio de Janeiro. The program will provide training and establish long-term collaborations with young investigators from Brazil, a country with high incidence of tuberculosis and indadequate tuberculosis control programs. A four-tiered training program has been designed to provide basic research skills to a large number of investigators and more intensive experiences for a smaller number of more select candidates with the potential to become leaders in TB and TB/HIV research in Brazil. Research training will be greatly augmented by the broad array of TB and TB/HIV research projects underway in Rio de Janeiro, all of which aim to reduce the burden of these two diseases. The result of this initiative will be a new cadre of clinically- and health services-oriented researchers who can make substantial contributions to the control of tuberculosis both in Brazil and globally in the next decade. ? ?

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Cooperative Agreements (U2R)
Project #
5U2RTW006883-04
Application #
7449748
Study Section
Special Emphasis Panel (ZRG1-ICP-2 (52))
Program Officer
Mcdermott, Jeanne
Project Start
2005-09-23
Project End
2010-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
4
Fiscal Year
2008
Total Cost
$349,075
Indirect Cost
Name
Federal University of Rio de Janeiro
Department
Type
DUNS #
900848466
City
Rio de Janeiro
State
Country
Brazil
Zip Code
21941-901
Cailleaux-Cezar, Michelle; Loredo, Carla; Silva, José Roberto Lapa E et al. (2018) Impact of smoking on sputum culture conversion and pulmonary tuberculosis treatment outcomes in Brazil: a retrospective cohort study. J Bras Pneumol 44:99-105
Ribeiro, Fabíola Karla Correa; Pan, William; Bertolde, Adelmo et al. (2015) Genotypic and Spatial Analysis of Mycobacterium tuberculosis Transmission in a High-Incidence Urban Setting. Clin Infect Dis 61:758-66
Maciel, Ethel Leonor; Reis-Santos, Bárbara (2015) Determinants of tuberculosis in Brazil: from conceptual framework to practical application. Rev Panam Salud Publica 38:28-34
do Prado, Thiago Nascimento; Miranda, Angélica Espinosa; de Souza, Fernanda Mattos et al. (2014) Factors associated with tuberculosis by HIV status in the Brazilian national surveillance system: a cross sectional study. BMC Infect Dis 14:415
Ferreira Junior, Sergio Luiz Montego; Dalla Costa, Elis Regina; Santos, Paula Gonçalves dos et al. (2014) In house reverse membrane hybridisation assay versus GenoType MTBDRplus and their performance to detect mutations in the genes rpoB, katG and inhA. Mem Inst Oswaldo Cruz 109:307-14
Nunes, Luciana de S; Baethgen, Ludmila F; Ribeiro, Marta O et al. (2014) Outbreaks due to Mycobacterium abscessus subsp. bolletii in southern Brazil: persistence of a single clone from 2007 to 2011. J Med Microbiol 63:1288-93
Ribeiro Macedo, L; Reis-Santos, B; Riley, L W et al. (2013) Treatment outcomes of tuberculosis patients in Brazilian prisons: a polytomous regression analysis. Int J Tuberc Lung Dis 17:1427-34
Trajman, A; Steffen, R E; Menzies, D (2013) Interferon-Gamma Release Assays versus Tuberculin Skin Testing for the Diagnosis of Latent Tuberculosis Infection: An Overview of the Evidence. Pulm Med 2013:601737
Soares, E C C; Vollmer, W M; Cavalcante, S C et al. (2013) Tuberculosis control in a socially vulnerable area: a community intervention beyond DOT in a Brazilian favela. Int J Tuberc Lung Dis 17:1581-6
Bastos, M L; Menzies, D; Belo, M T C T et al. (2013) Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection. Int J Tuberc Lung Dis 17:909-16

Showing the most recent 10 out of 62 publications