Abstract

The Management/Dissemination Core will continue to ensure effective execution of our project and the ready access of the public to the resources that we produce. We will continue with our current management structure, which has been very effective. We have worked extensively with the ENCODE DCC to make all our data and metadata available through their website. We will continue to submit our data to the DCC on regular basis. The collaboration with the DCC ensures that our project meets the most demanding standards of scientific rigor and transparency. The worm and fly model organisms gives us exceptional control over genetic and environmental variables.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Biotechnology Resource Cooperative Agreements (U41)
Project #
2U41HG007355-05
Application #
9416809
Study Section
Special Emphasis Panel (ZHG1)
Project Start
Project End
Budget Start
2018-06-01
Budget End
2019-03-31
Support Year
5
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Kudron, Michelle M; Victorsen, Alec; Gevirtzman, Louis et al. (2018) The ModERN Resource: Genome-Wide Binding Profiles for Hundreds of Drosophila and Caenorhabditis elegans Transcription Factors. Genetics 208:937-949
Cao, Junyue; Packer, Jonathan S; Ramani, Vijay et al. (2017) Comprehensive single-cell transcriptional profiling of a multicellular organism. Science 357:661-667
Sin, Olga; de Jong, Tristan; Mata-Cabana, Alejandro et al. (2017) Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation. Mol Cell 65:1096-1108.e6
Weicksel, Steven E; Mahadav, Assaf; Moyle, Mark et al. (2016) A novel small molecule that disrupts a key event during the oocyte-to-embryo transition in C. elegans. Development 143:3540-3548
Thompson, Owen A; Snoek, L Basten; Nijveen, Harm et al. (2015) Remarkably Divergent Regions Punctuate the Genome Assembly of the Caenorhabditis elegans Hawaiian Strain CB4856. Genetics 200:975-89
Cheng, Chao; Andrews, Erik; Yan, Koon-Kiu et al. (2015) An approach for determining and measuring network hierarchy applied to comparing the phosphorylome and the regulome. Genome Biol 16:63
Wang, Daifeng; Yan, Koon-Kiu; Sisu, Cristina et al. (2015) Loregic: a method to characterize the cooperative logic of regulatory factors. PLoS Comput Biol 11:e1004132
Kasper, Dionna M; Wang, Guilin; Gardner, Kathryn E et al. (2014) The C. elegans SNAPc component SNPC-4 coats piRNA domains and is globally required for piRNA abundance. Dev Cell 31:145-58
Gerstein, Mark B; Rozowsky, Joel; Yan, Koon-Kiu et al. (2014) Comparative analysis of the transcriptome across distant species. Nature 512:445-8