This cytokine receptor binds an important cytokine involved in diverse cellular regulatory activity. The structure will help understanding the cytokinefs related cellular activity and perhaps able to modulate this activity. Crystals have been grown in a tetragonal space group with cell edges 50 x 50 x 300 A. Crystals are very radiation sensitive, and current freezing techniques have caused some kind of disorder in the lattice. Two hour exposures on a rotating anode give diffraction data up to 3.5A. It is expected that better than 3A data can be obtained at the APS.

Project Start
1999-08-15
Project End
2000-08-14
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
8
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
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Horsman, Geoff P; Ke, Jiyuan; Dai, Shaodong et al. (2006) Kinetic and structural insight into the mechanism of BphD, a C-C bond hydrolase from the biphenyl degradation pathway. Biochemistry 45:11071-86