Determination of virus structures including (1) Porcine parvovirus capsids.
The aim will be to collect as complete a data set as possible in order to determine the 3 dimensional structure of this virus. At present insufficient crystallographic data is available to determine the structure of this virus, because we can obtain 3 or fewer diffraction images from each crystal. (2) Rhinovirus drug dependent mutant.
Aim i s to study the mechanism of drug resistance in rhinovirus. (3) Coxsackie virus.
The aim will be to collect a complete data set and determine the structure, for comparison with other picomaviruses and to study its interaction with the host receptor.
| Durbin, S M; Clevenger, T; Graber, T et al. (2012) X-ray pump optical probe cross-correlation study of GaAs. Nat Photonics 6:111-114 |
| Neutze, Richard; Moffat, Keith (2012) Time-resolved structural studies at synchrotrons and X-ray free electron lasers: opportunities and challenges. Curr Opin Struct Biol 22:651-9 |
| Horsman, Geoff P; Ke, Jiyuan; Dai, Shaodong et al. (2006) Kinetic and structural insight into the mechanism of BphD, a C-C bond hydrolase from the biphenyl degradation pathway. Biochemistry 45:11071-86 |
