Abstract

Focus on determining the crystal structures of potential drug targets from three different human bacterial pathogens. The proteins are related to tuberculosis, Lyme disease and resistant staph. MAD experiments on BioCARS Station 14-BM-C should yield valuable data.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Cooperative Agreements (U41)
Project #
5U41RR007707-10
Application #
6483508
Study Section
Project Start
2001-08-15
Project End
2002-08-14
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
10
Fiscal Year
2001
Total Cost
$120,630
Indirect Cost

  Publications

Durbin, S M; Clevenger, T; Graber, T et al. (2012) X-ray pump optical probe cross-correlation study of GaAs. Nat Photonics 6:111-114
Neutze, Richard; Moffat, Keith (2012) Time-resolved structural studies at synchrotrons and X-ray free electron lasers: opportunities and challenges. Curr Opin Struct Biol 22:651-9
Horsman, Geoff P; Ke, Jiyuan; Dai, Shaodong et al. (2006) Kinetic and structural insight into the mechanism of BphD, a C-C bond hydrolase from the biphenyl degradation pathway. Biochemistry 45:11071-86