Abstract

A safe and effective vaccine remains the best hope of controlling the human immunodeficiency virus (HIV) pandemic. Because of the similarity of the immune system of the Indian-origin rhesus macaques and humans, vaccine development is heavily dependent on the SIV and SHIV macaque models. The need for Indian rhesus macaques for AIDS-related research continues to exceed availability. Efficient domestic breeding programs managed to produce well characterized animals that enhance their use in biomedical research and offer the best long term solution for the current shortage of Indian-origin rhesus macaques for AIDS vaccine and pathogenesis studies and to insure future availability. The purposes of this proposal are to continue to support and characterize the specific pathogen-free Indian rhesus AIDS Research Colony resource that was established in the past ten-year grant period.

Public Health Relevance

The objective of this application is to continue to maintain and genetically characterize the colony to maximize the usefulness in biomedical research. The colony was initiated in 2001 and now provides approximately 200 macaques for U.S. Public Health Service supported AIDS research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Materials Resource Cooperative Agreements (U42)
Project #
5U42OD010426-12
Application #
8601761
Study Section
Special Emphasis Panel (ZTR1-CM-6 (01))
Program Officer
Contreras, Miguel A
Project Start
2013-01-01
Project End
2016-12-31
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
12
Fiscal Year
2014
Total Cost
$322,133
Indirect Cost
$138,057

  Institution

Name
Oregon Health and Science University
Department
Veterinary Sciences
Type
Other Domestic Higher Education
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Hessell, Ann J; Shapiro, Mariya B; Powell, Rebecca et al. (2018) Reduced cell-associated DNA and improved viral control in macaques following passive transfer of a single anti-V2 monoclonal antibody and repeated SHIV challenges. J Virol :
Eghlidi, Dominique H; Luna, Selva L; Brown, Donald I et al. (2018) Gene expression profiling of the SCN in young and old rhesus macaques. J Mol Endocrinol 61:57-67
Hansen, Scott G; Zak, Daniel E; Xu, Guangwu et al. (2018) Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine. Nat Med 24:130-143
Oberst, Michael D; Augé, Catherine; Morris, Chad et al. (2018) Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein. Mol Cancer Ther 17:1024-1038
Rais, Maham; Wilson, Randall M; Urbanski, Henryk F et al. (2017) Androgen supplementation improves some but not all aspects of immune senescence in aged male macaques. Geroscience 39:373-384
Eghlidi, Dominique H; Garyfallou, Vasilios T; Kohama, Steven G et al. (2017) Age-associated gene expression changes in the arcuate nucleus of male rhesus macaques. J Mol Endocrinol 59:141-149
Urbanski, Henryk F (2017) Effect of androgen supplementation on 24-hour activity-rest patterns of aged male rhesus macaques. Neurobiol Aging 54:100-102
McBurney, Sean P; Sunshine, Justine E; Gabriel, Sarah et al. (2016) Evaluation of protection induced by a dengue virus serotype 2 envelope domain III protein scaffold/DNA vaccine in non-human primates. Vaccine 34:3500-7
Yee, JoAnn L; Vanderford, Thomas H; Didier, Elizabeth S et al. (2016) Specific pathogen free macaque colonies: a review of principles and recent advances for viral testing and colony management. J Med Primatol 45:55-78
DeGottardi, Maren Q; Okoye, Afam A; Vaidya, Mukta et al. (2016) Effect of Anti-IL-15 Administration on T Cell and NK Cell Homeostasis in Rhesus Macaques. J Immunol 197:1183-98

Showing the most recent 10 out of 52 publications