, Overall A safe, effective vaccine continues to be the best hope for controlling the Human Immunodeficiency Virus (HIV) pandemic. Due to similarities between the Indian-origin rhesus macaque (Macaca mulatta) and human immune systems, vaccine development as well as other approaches for controlling AIDS are heavily dependent upon the SIV and SHIV macaque models. There is a continuing need for Indian-origin rhesus macaques to support this work. Efficient domestic breeding programs, effectively managed to produce well characterized animals, with enhanced usefulness in biomedical research offer the best solution to ensuring the supply of Indian-origin rhesus macaques for AIDS vaccine development and other treatment and pathogenesis studies. The purpose of this proposal is to provide support for the genetically characterized, specific pathogen free, Indian-origin rhesus macaque AIDS Research Colony resource that was established in 2001 at the Oregon National Primate Research Center.

Public Health Relevance

The specific aims in this proposal are designed to continue our current efforts to maintain a genetically diverse MHC-defined SPF Indian-origin rhesus macaque colony targeting AIDS-related research focused on the use of opportunistic viral agents as vaccine vectors, as well as other approaches to AIDS prevention and treatment.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Materials Resource Cooperative Agreements (U42)
Project #
5U42OD010426-17
Application #
9657841
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Chang, Michael
Project Start
2013-01-01
Project End
2021-02-28
Budget Start
2019-03-01
Budget End
2020-02-29
Support Year
17
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Veterinary Sciences
Type
Primate Centers
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
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