Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Materials Resource Cooperative Agreements (U42)
Project #
5U42RR016598-04
Application #
6802233
Study Section
Special Emphasis Panel (ZRR1-CR-6 (01))
Program Officer
Rosenblum, Daniel
Project Start
2001-09-30
Project End
2006-08-31
Budget Start
2004-09-01
Budget End
2005-08-31
Support Year
4
Fiscal Year
2004
Total Cost
$1,253,478
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Surgery
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Loganathan, Gopalakrishnan; Graham, Melanie L; Radosevich, David M et al. (2013) Factors affecting transplant outcomes in diabetic nude mice receiving human, porcine, and nonhuman primate islets: analysis of 335 transplantations. Transplantation 95:1439-47
Kaddis, John S; Hanson, Matthew S; Cravens, James et al. (2013) Standardized transportation of human islets: an islet cell resource center study of more than 2,000 shipments. Cell Transplant 22:1101-11
Avgoustiniatos, Efstathios S; Scott 3rd, William E; Suszynski, Thomas M et al. (2012) Supplements in human islet culture: human serum albumin is inferior to fetal bovine serum. Cell Transplant 21:2805-14
Bellin, M D; Barton, F B; Heitman, A et al. (2012) Potent induction immunotherapy promotes long-term insulin independence after islet transplantation in type 1 diabetes. Am J Transplant 12:1576-83
Balamurugan, A N; Loganathan, Gopalakrishnan; Bellin, Melena D et al. (2012) A new enzyme mixture to increase the yield and transplant rate of autologous and allogeneic human islet products. Transplantation 93:693-702
Loganathan, Gopalakrishnan; Dawra, Rajinder K; Pugazhenthi, Subbiah et al. (2011) Insulin degradation by acinar cell proteases creates a dysfunctional environment for human islets before/after transplantation: benefits of ?-1 antitrypsin treatment. Transplantation 92:1222-30
Anazawa, Takayuki; Matsumoto, Shuichiro; Yonekawa, Yukihide et al. (2011) Prediction of pancreatic tissue densities by an analytical test gradient system before purification maximizes human islet recovery for islet autotransplantation/allotransplantation. Transplantation 91:508-14
Loganathan, G; Dawra, R K; Pugazhenthi, S et al. (2010) Culture of impure human islet fractions in the presence of alpha-1 antitrypsin prevents insulin cleavage and improves islet recovery. Transplant Proc 42:2055-7
Scott 3rd, W E; O'Brien, T D; Ferrer-Fabrega, J et al. (2010) Persufflation improves pancreas preservation when compared with the two-layer method. Transplant Proc 42:2016-9
Kaddis, J S; Danobeitia, J S; Niland, J C et al. (2010) Multicenter analysis of novel and established variables associated with successful human islet isolation outcomes. Am J Transplant 10:646-56

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