A primary goal of this application is the development of new vaccines, diagnostics, and therapeuticsfor category A-C priority agents. Animal models will be needed to improve our understanding of the hostpathogenrelationship and to test newly developed products. Since many of the pathogens require BSL-3containment, state-of-the-art BSL-3 vivaria will be critical in reaching our research goals. Thus, we haveestablished an Animal Core in order to the meet the current and expanding needs of NBC scientists. Theobjectives of the Animal Core are: 1) to provide high quality BSL-3 animal facilities; 2) to advise and traininvestigators in animal models for category A-C priority agents; and 3) to encourage collaborations betweenNBC members.The NBC Animal Core consists of BSL-3 vivaria at four sites within region 2 and provides facilities fora wide variety of animal species. Small animal studies involving rodents, rabbits, and birds will be performedat one of two BSL-3 vivaria at PHRI, Newark, NJ or Wadsworth Center, Albany, NY. Studies in livestock onzoonotic pathogens will be located at the Plum Island Animal Disease Center, Plum Island, NY. Non-humanprimate studies will be conducted at the Caribbean Primate Research Center, Puerto Rico. The diversity ofanimal species available at these four facilities is essential in order to address the diversity of the categoryA-C priority agents. In addition, the diverse scientific expertise at these facilities will provide excellent trainingand collaborative opportunities for the NBC research community.
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