This application aims to facilitate research on eosinophilic esophagitis (EoE), eosinophilic gastritis (EG), and eosinophilic colitis (EC) through the development of a Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). CEGIR comprises clinical centers in Ohio (the coordinating center), Colorado, California, Indiana, Pennsylvania, Illinois, North Carolina, Massachusetts, Switzerland, and Maryland. All participating domestic, non-National Institutes of Health (NIH) clinical centers are associated with a Clinical Translational Science Award (CTSA). The CEGIR sites have been carefully chosen on the basis of their preexisting record of collaboration with each other;diverse expertise in relevant clinical specialties including Gastroenterology, Allergy, Immunology, and Pathology;the ability to integrate pediatric and adult patients into a common consortium;and well-established record of excellence in clinical research involving this patient population. Importantly, the CEGIR sites have proven access to an adequate number of patients with the rare diseases studied, as evidenced from the recent completion of the first set of controlled clinical trials involving this patient population. Strong patient advocacy groups (PAGs), including the American Partnership for Eosinophilic Disorders (APFED) and the Campaign Urging Research for Eosinophilic Disease (CURED), already partner with the CEGIR Investigators and will continue to work synergistically in the context of CEGIR. Despite the recent record of advances by CEGIR Investigators, the early success of their collaborative interactions, the proactive PAGs, and the development of novel anti-eosinophil therapeutics, there is no currently existing funding for a clinical network focusing on these three rare, distinct diseases, highlightig the timeliness and importance of this application.

Public Health Relevance

Eosinophilic esophagitis, eosinophilic gastritis, and eosinophilic colitis are painful, lifelong diseases that make it difficult or impossible for indiviuals to eat many or all foods. Individuals with these diseases often have to fuel their bodies by drinking costly formulas. We will partner with researchers, patients, and other key groups, including patient advocacy groups, to better understand, treat, and educate about these diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54AI117804-01
Application #
8764284
Study Section
Special Emphasis Panel (ZTR1-CI-8 (01))
Program Officer
Minnicozzi, Michael
Project Start
2014-08-15
Project End
2019-07-31
Budget Start
2014-08-15
Budget End
2015-07-31
Support Year
1
Fiscal Year
2014
Total Cost
$1,250,000
Indirect Cost
$275,166
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Kottyan, Leah; Spergel, Jonathan M; Cianferoni, Antonella (2018) Immunology of the ancestral differences in eosinophilic esophagitis. Ann Allergy Asthma Immunol :
Chehade, Mirna; Jones, Stacie M; Pesek, Robbie D et al. (2018) Phenotypic Characterization of Eosinophilic Esophagitis in a Large Multicenter Patient Population from the Consortium for Food Allergy Research. J Allergy Clin Immunol Pract 6:1534-1544.e5
Dellon, Evan S; Liacouras, Chris A; Molina-Infante, Javier et al. (2018) Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference. Gastroenterology 155:1022-1033.e10
Dellon, Evan S; Hirano, Ikuo (2018) Epidemiology and Natural History of Eosinophilic Esophagitis. Gastroenterology 154:319-332.e3
Wright, Benjamin L; Nguyen, Nathalie; Shim, Kelly P et al. (2018) Increased GATA-3 and T-bet expression in eosinophilic esophagitis versus gastroesophageal reflux disease. J Allergy Clin Immunol 141:1919-1921.e5
Godwin, Bridget; Liacouras, Chris; Mehta, Vijay et al. (2018) A Review of Tertiary Referrals for Management of Pediatric Esophageal Eosinophilia. Front Pediatr 6:173
Hiremath, Girish; Kodroff, Ellyn; Strobel, Mary J et al. (2018) Individuals affected by eosinophilic gastrointestinal disorders have complex unmet needs and frequently experience unique barriers to care. Clin Res Hepatol Gastroenterol 42:483-493
Hiremath, Girish; Vaezi, Michael F; Gupta, Sandeep K et al. (2018) Management of Esophageal Food Impaction Varies Among Gastroenterologists and Affects Identification of Eosinophilic Esophagitis. Dig Dis Sci 63:1428-1437
Patel, Ronak Vashi; Hirano, Ikuo (2018) New Developments in the Diagnosis, Therapy, and Monitoring of Eosinophilic Esophagitis. Curr Treat Options Gastroenterol 16:15-26
Jensen, Elizabeth T; Dellon, Evan S (2018) Environmental factors and eosinophilic esophagitis. J Allergy Clin Immunol 142:32-40

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