Protein-protein interactions are an integral component of many sections of this proposal. This DBP focuses on an important family of proteins, the cadherins, whose binding specificity plays a central role in cell-cell adhesion. Our goal is to understand the molecular basis of the binding specificity of cadherins and, in turn, the structural basis of many cell-cell adhesion processes. The fundamental question to be addressed concerns how cadherins are able to bind to one another at the cellular level in a homophilic fashion, even though many cadherins are closely related to one another in sequence, and thus might be expected to cross-react. Indeed heterophilic binding is sometimes observed in in-vitro measurements. In addition, we wish to understand the diverse function of different cadherins and to see how different cadherin subfamilies have evolved to carry out distinct, albeit related functions.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA121852-04
Application #
7676858
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
4
Fiscal Year
2008
Total Cost
$284,261
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
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