Core C: Peptides - The overall mission of the Peptide Core is to provide the resources and services needed to select, screen, sequence, synthesize, label, and analyze the peptides to be used in the Primary and Task Specific Projects for preferential binding and detection of dysplasia in the gastrointestinal tract. Chung Owyang, MD is the Director of Core C: Peptides for this proposed NTR Research Center. Dr. Owyang is also the P.I. of the Gastroenterology Peptide Research Core Center at the University of Michigan, an NIH/NIDDK funded Digestive Disease Center whose mission is to investigate the functional properties and signaling mechanisms of gut peptides. He provides a wealth of experience for guiding research in the peptide binding interactions and target identification of cell surface receptors associated with neoplastic transformation in the digestive tract. Henriette Remmer, PhD, is the Co-Director of this Core. She is also the Director of the Protein Structure Core Facility at the University of Michigan, and has significant experience in techniques of peptide synthesis and protein structure analysis. Dr. Remmer will be available to the network investigators as a resource for consultation regarding all steps of development, synthesis, and analysis of peptides as probes for the detection of pre-malignant mucosa in the digestive tract. Henriette Remmer, PhD, is the Co-Director of this Core. She is also the Director of the Protein Structure Core Facility at the University of Michigan, and has significant experience in techniques of peptide synthesis and protein structure analysis. Dr. Remmer will be available to the network investigators as a resource for consultation regarding all steps of development, synthesis, and analysis of peptides as probes for the detection of pre-malignant mucosa in the digestive tract. Xiaoju (George) Wang, Ph.D is also a Co-Director for Core C: Peptides for this NTR Research Center. Dr. G Wang has significant experience in techniques of phage display, in particular with employing high-throughput phage epitope microarrays and multiplexed protein/epitope microarrays. These resources will be valuable for performing peptide screening to identify optimal candidates for subsequent clinical use, and will be available to all of the investigators in the network.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA136429-05
Application #
8381401
Study Section
Special Emphasis Panel (ZCA1-SRRB-9)
Project Start
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
5
Fiscal Year
2012
Total Cost
$37,026
Indirect Cost
$11,777
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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Sturm, Matthew B; Joshi, Bishnu P; Lu, Shaoying et al. (2013) Targeted imaging of esophageal neoplasia with a fluorescently labeled peptide: first-in-human results. Sci Transl Med 5:184ra61

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