Abstract

TASK-SPECIFIC PROJECTS INTRODUCTION TO TASK-SPECIFIC PROJECTS We have selected two task-specific projects for the first year of this program that support aim 1 with the development of gastric cancer probes in task-specific project 1, and Raman particle-based molecular instruments and probes in task-specific project 2. The intent is to support early development in the first years of the program and move towards translation with the task-specific projects in the out years. In task-specific project 1 the investigators will screen phage display libraries for early markers of gastric cancer using tissue from high-risk individuals. In task-specific project 2 the team will evaluate Raman instrumentation and nanoparticles as tools for multiplexed early detection and disease staging. Imaging instrumentation has been, in many cases, well-developed but the molecular markers of disease for use with these instruments has lagged behind, and this is one reason for an emphasis on molecular probes in this program and in the early task-specific projects. With our task-specific projects have decided to invest significantly in the reagents side of the molecular imaging field because we feel these will have a significant impact on disease management, will complement our current strengths in instrumentation, and build on our recent successes in clinical translation of molecular probes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA136465-05
Application #
8379281
Study Section
Special Emphasis Panel (ZCA1-SRRB-9)
Project Start
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
5
Fiscal Year
2012
Total Cost
$51,045
Indirect Cost
$12,146

  Institution

Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Uddin, Md Jashim; Moore, Chauca E; Crews, Brenda C et al. (2016) Fluorocoxib A enables targeted detection of cyclooxygenase-2 in laser-induced choroidal neovascularization. J Biomed Opt 21:90503
Uddin, Md Jashim; Werfel, Thomas A; Crews, Brenda C et al. (2016) Fluorocoxib A loaded nanoparticles enable targeted visualization of cyclooxygenase-2 in inflammation and cancer. Biomaterials 92:71-80
Sensarn, Steven; Zavaleta, Cristina L; Segal, Ehud et al. (2016) A Clinical Wide-Field Fluorescence Endoscopic Device for Molecular Imaging Demonstrating Cathepsin Protease Activity in Colon Cancer. Mol Imaging Biol 18:820-829
Ra, Hyejun; González-González, Emilio; Uddin, Md Jashim et al. (2015) Detection of non-melanoma skin cancer by in vivo fluorescence imaging with fluorocoxib A. Neoplasia 17:201-7
Templeton, Zachary S; Bachmann, Michael H; Alluri, Rajiv V et al. (2015) Methods for culturing human femur tissue explants to study breast cancer cell colonization of the metastatic niche. J Vis Exp :
Uddin, Md Jashim; Crews, Brenda C; Ghebreselasie, Kebreab et al. (2015) Targeted imaging of cancer by fluorocoxib C, a near-infrared cyclooxygenase-2 probe. J Biomed Opt 20:50502
Rogalla, Stephan; Contag, Christopher H (2015) Early Cancer Detection at the Epithelial Surface. Cancer J 21:179-87
Garai, Ellis; Sensarn, Steven; Zavaleta, Cristina L et al. (2015) A real-time clinical endoscopic system for intraluminal, multiplexed imaging of surface-enhanced Raman scattering nanoparticles. PLoS One 10:e0123185
Contag, Christopher H; Lie, Wen-Rong; Bammer, Marie C et al. (2014) Monitoring dynamic interactions between breast cancer cells and human bone tissue in a co-culture model. Mol Imaging Biol 16:158-66
Ajithkumar, G; Yoo, Benjamin; Goral, Dara E et al. (2013) Multimodal bioimaging using rare earth doped Gd2O2S: Yb/Er phosphor with upconversion luminescence and magnetic resonance properties. J Mater Chem A Mater 1:1561-1572

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