The Charies Drew University (CDU) UCLJ Cancer Center Partnership proposes to develop an outreach program designed to promote cancer prevention and control, and improve the quality of life and cancer-related outcomes among minority and socioeconomically disadvantaged populations. The Outreach Program will primarily focus on providing knowledge transfer activities?a two-way transfer of knowledge, ideas, concerns, expertise, and results between academia, healthcare providers, lay community, government, and other stakeholders?to disseminate current evidence-based knowledge from academia to community and experience-based knowledge from community to academia. The proposed CDU Outreach Program will build upon the cancer community outreach programs existing at UCLA and the current community outreach activities at CDU. The Outreach Program was designed and will be co-directed by Keith Norris at CDU, Dr. Roshan Bastani and Dr. Annette Maxwell at UCLA-JCCC, and Loretta Jones of Healthy African-American Families (HAAF), a community-based organization. Specifically the Outreach program at CDU will include community-partnered participatory research (CPPR) principles, a community-academic model developed by Loretta Jones and Keith Norris. The CPPR approach ensures that the core tenets of partner equity in CBPR are embedded, as distinguished from academic designed or community-placed research, both of which are valuable approaches but are not partner equity projects. Dr. Norris and Ms. Jones have been successful in using this model in the areas of depression, diabetes, preterm health, and kidney disease. Using the CPPR model, the Partnership will foster cancer outreach and knowledge transfer. CPPR's partnering processes will be used to provide cancer outreach to community, disseminate cancer research findings, and cultivate ongoing community-academic cancer research. The Partnership is positioned perfectly to stimulate cancer prevention, early detection, and control in the community using the CPPR model.
The Specific aims for the cancer outreach program are:
Specific Aim 1 : Community engagement: Integrate community participation with ongoing research at UCLA and CDU (including student research projects and proposed pilot and full projects in the U54);
Specific Aim 2 : CBPR: Enhance community and university capacity and relationships to support cancer education, information dissemination, and cancer prevention and control;
Specific Aim 3 : CBPR: Provide knowledge transfer activities to disseminate current evidence-based cancer control knowledge from academia to community and experience-based knowledge from community to academia;
and Specific Aim 4 : CPPR: Generate shared community partnered research projects including active engagement in research design, implementation, data analysis, manuscripts, policy recommendations, and dissemination strategies to address cancer disparities in South Los Angeles.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA143930-03
Application #
8308603
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
3
Fiscal Year
2011
Total Cost
$100,369
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Boonyaratanakornkit, Viroj; Hamilton, Nalo; Márquez-Garbán, Diana C et al. (2018) Extranuclear signaling by sex steroid receptors and clinical implications in breast cancer. Mol Cell Endocrinol 466:51-72
Elshimali, Yahya I; Wu, Yong; Khaddour, Hussein et al. (2018) Optimization Of Cancer Treatment Through Overcoming Drug Resistance. J Cancer Res Oncobiol 1:
Maxwell, Annette E; Crespi, Catherine M; Arce, Anthony A et al. (2017) Exploring the effects of longstanding academic-community partnerships on study outcomes: A case study. Prev Med Rep 8:101-107
Hamilton, Nalo; Austin, David; Márquez-Garbán, Diana et al. (2017) Receptors for Insulin-Like Growth Factor-2 and Androgens as Therapeutic Targets in Triple-Negative Breast Cancer. Int J Mol Sci 18:
Wu, Y; Vadgama, J V (2017) Androgen Receptor as a Potential Target for Treatment of Breast Cancer. Int J Cancer Res Mol Mech 3:
Wu, Yong; Yu, Xiaoting; Yi, Xianghua et al. (2017) Aberrant Phosphorylation of SMAD4 Thr277-Mediated USP9x-SMAD4 Interaction by Free Fatty Acids Promotes Breast Cancer Metastasis. Cancer Res 77:1383-1394
Bhat, Kruttika; Sarkissyan, Marianna; Wu, Yanyuan et al. (2017) GRO? overexpression drives cell migration and invasion in triple negative breast cancer cells. Oncol Rep 38:21-30
Wu, Yanyuan; Tran, Trinh; Dwabe, Sami et al. (2017) A83-01 inhibits TGF-?-induced upregulation of Wnt3 and epithelial to mesenchymal transition in HER2-overexpressing breast cancer cells. Breast Cancer Res Treat 163:449-460
Gelfand, Robert; Vernet, Dolores; Bruhn, Kevin W et al. (2017) Long-term exposure of MCF-7 breast cancer cells to ethanol stimulates oncogenic features. Int J Oncol 50:49-65
Dong, Yunzhou; Wu, Yong; Cui, Mei-Zhen et al. (2017) Lysophosphatidic Acid Triggers Apoptosis in HeLa Cells through the Upregulation of Tumor Necrosis Factor Receptor Superfamily Member 21. Mediators Inflamm 2017:2754756

Showing the most recent 10 out of 52 publications