The PS-OC is itself a highly collaborative structure as virtually every key member of the PS-OC is involved in multiple projects and infrastructure components. Additional collaborations within the PS-OC will be encouraged through weekly conferences in the IMO at Moffitt, monthly videoconferences of the PS-OC research groups, and face-to-face interactions that will occur through the summer school and yearly international conference both sponsored by the PS-OC. We have placed a facilitator in the mathematics/computation core to promote the often difficult initial steps in these multidisciplinary interactions. Further collaborations will be encouraged through the co-mentoring of PhD students described in section N3. We will also encourage collaborations with members of other PS-OCs by providing funding for a visiting scholar program that will each year fund 10 scholars to spend an average of 3 months (range from 1 to 6 months) in one component of the IMO PS-OC. Similarly, funds will be set aside for members of the IMO PS-OC to visit other sites to either obtain advanced training or use research/educational facilities that might be unique to that site.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA143970-04
Application #
8555193
Study Section
Special Emphasis Panel (ZCA1-SRLB-9 (O1))
Project Start
2009-09-30
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
4
Fiscal Year
2012
Total Cost
$200,263
Indirect Cost
$71,416
Name
H. Lee Moffitt Cancer Center & Research Institute
Department
Type
DUNS #
139301956
City
Tampa
State
FL
Country
United States
Zip Code
33612
Gatenby, Robert; Brown, Joel (2018) The Evolution and Ecology of Resistance in Cancer Therapy. Cold Spring Harb Perspect Med 8:
Gravenmier, Curtis A; Siddique, Miriam; Gatenby, Robert A (2018) Adaptation to Stochastic Temporal Variations in Intratumoral Blood Flow: The Warburg Effect as a Bet Hedging Strategy. Bull Math Biol 80:954-970
Ibrahim-Hashim, Arig; Robertson-Tessi, Mark; Enriquez-Navas, Pedro M et al. (2017) Defining Cancer Subpopulations by Adaptive Strategies Rather Than Molecular Properties Provides Novel Insights into Intratumoral Evolution. Cancer Res 77:2242-2254
Brown, Joel S; Cunningham, Jessica J; Gatenby, Robert A (2017) Aggregation Effects and Population-Based Dynamics as a Source of Therapy Resistance in Cancer. IEEE Trans Biomed Eng 64:512-518
Perfahl, Holger; Hughes, Barry D; Alarcón, Tomás et al. (2017) 3D hybrid modelling of vascular network formation. J Theor Biol 414:254-268
de Groot, Amber E; Roy, Sounak; Brown, Joel S et al. (2017) Revisiting Seed and Soil: Examining the Primary Tumor and Cancer Cell Foraging in Metastasis. Mol Cancer Res 15:361-370
Gatenby, Robert A; Frieden, B Roy (2017) Cellular information dynamics through transmembrane flow of ions. Sci Rep 7:15075
McFarland, Christopher D; Yaglom, Julia A; Wojtkowiak, Jonathan W et al. (2017) The Damaging Effect of Passenger Mutations on Cancer Progression. Cancer Res 77:4763-4772
Zhang, Jingsong; Cunningham, Jessica J; Brown, Joel S et al. (2017) Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer. Nat Commun 8:1816
Zhang, Xiaomeng; Wojtkowiak, Jonathan W; Martinez, Gary V et al. (2016) MR Imaging Biomarkers to Monitor Early Response to Hypoxia-Activated Prodrug TH-302 in Pancreatic Cancer Xenografts. PLoS One 11:e0155289

Showing the most recent 10 out of 121 publications