Abstract

The Administrative Core will play a central and critical role in the mission of the EMDR Center by integrating the activities of the 3 research projects, by promoting and supporting their interaction with other academic entities at CHLA, USC and COH and by supporting the networking with the TMEN community and the scientific community at large. The ulfimate goal of all these activifies is to improve the survival not only of children with ALL and neuroblastoma but all patients with cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA163117-02
Application #
8555324
Study Section
Special Emphasis Panel (ZCA1-SRLB-3 (O1))
Project Start
2011-09-20
Project End
2016-07-31
Budget Start
2012-09-20
Budget End
2013-07-31
Support Year
2
Fiscal Year
2012
Total Cost
$126,862
Indirect Cost
$45,016

  Institution

Name
Children's Hospital of Los Angeles
Department
Type
DUNS #
052277936
City
Los Angeles
State
CA
Country
United States
Zip Code
90027

  Publications

Hadjidaniel, Michael D; Muthugounder, Sakunthala; Hung, Long T et al. (2017) Tumor-associated macrophages promote neuroblastoma via STAT3 phosphorylation and up-regulation of c-MYC. Oncotarget 8:91516-91529
Lifshitz, Veronica; Priceman, Saul J; Li, Wenzhao et al. (2017) Sphingosine-1-Phosphate Receptor-1 Promotes Environment-Mediated and Acquired Chemoresistance. Mol Cancer Ther 16:2516-2527
Nakata, Rie; Shimada, Hiroyuki; Fernandez, G Esteban et al. (2017) Contribution of neuroblastoma-derived exosomes to the production of pro-tumorigenic signals by bone marrow mesenchymal stromal cells. J Extracell Vesicles 6:1332941
DeClerck, Yves A; Pienta, Kenneth J; Woodhouse, Elisa C et al. (2017) The Tumor Microenvironment at a Turning Point Knowledge Gained Over the Last Decade, and Challenges and Opportunities Ahead: A White Paper from the NCI TME Network. Cancer Res 77:1051-1059
Borriello, Lucia; Nakata, Rie; Sheard, Michael A et al. (2017) Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells. Cancer Res 77:5142-5157
Borriello, Lucia; Seeger, Robert C; Asgharzadeh, Shahab et al. (2016) More than the genes, the tumor microenvironment in neuroblastoma. Cancer Lett 380:304-14
Yue, Chanyu; Shen, Shudan; Deng, Jiehui et al. (2015) STAT3 in CD8+ T Cells Inhibits Their Tumor Accumulation by Downregulating CXCR3/CXCL10 Axis. Cancer Immunol Res 3:864-870
HaDuong, Josephine H; Blavier, Laurence; Baniwal, Sanjeev K et al. (2015) Interaction between bone marrow stromal cells and neuroblastoma cells leads to a VEGFA-mediated osteoblastogenesis. Int J Cancer 137:797-809
Bergfeld, Scott A; Blavier, Laurence; DeClerck, Yves A (2014) Bone marrow-derived mesenchymal stromal cells promote survival and drug resistance in tumor cells. Mol Cancer Ther 13:962-75
Borriello, Lucia; DeClerck, Yves A (2014) [Tumor microenvironment and therapeutic resistance process]. Med Sci (Paris) 30:445-51

Showing the most recent 10 out of 15 publications