The overarching goal of this Core is to provide the high degree of technical expertise required to perform and interpret advanced MR imaging studies;facilitate the collection of image guided surgical specimens;and relate the quantitative information derived from the imaging data to molecular markers of the biological properties of the tissue. It should be stressed that many of the procedures required to achieve this objective are nonstandard, requiring specialized knowledge, cutting-edge equipment, and sophisticated experimental or computer analysis in order to extract the information necessary for testing the hypotheses associated with each of the Scientific Projects. The decision to create a single Core that would integrate the imaging and tissue analysis reflects the high priority placed upon acquiring image-guided samples that can provide a direct link between the clinical imaging variables extracted from the noninvasive metabolic and physiologic imaging data and the tissue markers of tumor biology. The interaction of the Imaging and Tissue Procurement Core with the rest of the UCSF TMEN Brain Cancer Center is shown in the figure immediately below. Working closely with Co-Principal Investigators Gabriele Bergers and Valerie M. Weaver, Co-Project Leaders Joanna J. Phillips and Soonmee Cha will hold the primary responsibility for planning, directing, and executing the Imaging and Tissue Procurement activities ofthe TMEN U54 UCSF Brain Cancer Center. They will be assisted by the Administrative Core Manager Annette Bistrup and will exploit the Center's webpage for inquiries and protocols for tissue and imaging requests/requirements. The major purpose of the Core is to identify potential research subjects, schedule imaging acquisition, identify potential biopsy sites, procure tissue from the operating room, de-identify tissue samples, distribute fresh tumor tissue and paired non-tumor tissue, and properly handle and store tissue for future use. The Core will also provide expertise in neuroradiology, neuropathology, and morphologic analytical techniques to the UCSF TMEN Brain Cancer Center. In addition, the Core will provide training and information with respect to the analysis of imaging and pathology variables and the optimal use and handling of human tissue. Critical to the success of the TMEN Brain Cancer Center is access to primary brain tumor tissue and non-tumor tissue for analysis. The organizational structure for the Imaging and Tissue Procurement Core is depicted in the figure below. The progress of tissue procurement will be monitored through weekly teleconference meetings. Our goal is to obtain fresh tissue from 3 patients every 2 months for a total accrual of 90 patients over 5 years.
| Tharp, Kevin M; Weaver, Valerie M (2018) Modeling Tissue Polarity in Context. J Mol Biol 430:3613-3628 |
| Ilkhanizadeh, Shirin; Sabelström, Hanna; Miroshnikova, Yekaterina A et al. (2018) Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma. Mol Cancer Res 16:777-790 |
| Fan, QiWen; Aksoy, Ozlem; Wong, Robyn A et al. (2017) A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma. Cancer Cell 31:424-435 |
| Zhang, Jie; Yao, Tsun-Wen; Hashizume, Rintaro et al. (2017) Combined BRAFV600E and MEK blockade for BRAFV600E-mutant gliomas. J Neurooncol 131:495-505 |
| Allen, Elizabeth; Jabouille, Arnaud; Rivera, Lee B et al. (2017) Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation. Sci Transl Med 9: |
| Yao, Tsun-Wen; Zhang, Jie; Prados, Michael et al. (2017) Acquired resistance to BRAF inhibition in BRAFV600E mutant gliomas. Oncotarget 8:583-595 |
| Barnes, J Matthew; Przybyla, Laralynne; Weaver, Valerie M (2017) Tissue mechanics regulate brain development, homeostasis and disease. J Cell Sci 130:71-82 |
| Kai, FuiBoon; Laklai, Hanane; Weaver, Valerie M (2016) Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease. Trends Cell Biol 26:486-497 |
| Yu, Dan; Dong, Zhiqiang; Gustafson, William Clay et al. (2016) Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo. Protein Sci 25:308-15 |
| Przybyla, L; Lakins, J N; Sunyer, R et al. (2016) Monitoring developmental force distributions in reconstituted embryonic epithelia. Methods 94:101-13 |
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