The mission of our U54 entitled Biophysical and molecular dialogue of glioma cells and the brain microenvironment is to bring together experts from basic neurosciences, cancer biology, engineering, radiology, imaging, brain pathology, and surgery, and, as a team within the Center and within the national TMEN network, support and nurture an interdisciplinary environment and research that: (1) originates and tests novel, interdisciplinary-sciences based approaches to understanding, controlling and treating aggressive brain tumors; (2) generates orthogonal sets of physical and molecular measurements and integrates them with existing knowledge on brain tumors from the perspective of the tumor microenvironment; (3) develops and evaluates molecular and physical approaches to provide a comprehensive and dynamic picture of brain tumors that define the tissue microenvironment of high-grade gliomas; (4) disseminates these novel approaches and tools throughout the TMEN network and the larger scientific community; (5) exploits resources and scientific expertise within the UCSF scientific community; (6) leverages, efficiently and cost-effectively, existing NCI resources, both locally and nationally; and (7) educates the public and scientists at all levels (undergraduate to senior investigators) about the work and goals of the TMEN.
| Tharp, Kevin M; Weaver, Valerie M (2018) Modeling Tissue Polarity in Context. J Mol Biol 430:3613-3628 |
| Ilkhanizadeh, Shirin; Sabelström, Hanna; Miroshnikova, Yekaterina A et al. (2018) Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma. Mol Cancer Res 16:777-790 |
| Fan, QiWen; Aksoy, Ozlem; Wong, Robyn A et al. (2017) A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma. Cancer Cell 31:424-435 |
| Zhang, Jie; Yao, Tsun-Wen; Hashizume, Rintaro et al. (2017) Combined BRAFV600E and MEK blockade for BRAFV600E-mutant gliomas. J Neurooncol 131:495-505 |
| Allen, Elizabeth; Jabouille, Arnaud; Rivera, Lee B et al. (2017) Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation. Sci Transl Med 9: |
| Yao, Tsun-Wen; Zhang, Jie; Prados, Michael et al. (2017) Acquired resistance to BRAF inhibition in BRAFV600E mutant gliomas. Oncotarget 8:583-595 |
| Barnes, J Matthew; Przybyla, Laralynne; Weaver, Valerie M (2017) Tissue mechanics regulate brain development, homeostasis and disease. J Cell Sci 130:71-82 |
| Miroshnikova, Yekaterina A; Mouw, Janna K; Barnes, J Matthew et al. (2016) Tissue mechanics promote IDH1-dependent HIF1?-tenascin C feedback to regulate glioblastoma aggression. Nat Cell Biol 18:1336-1345 |
| Ou, Guanqing; Thakar, Dhruv; Tung, Jason C et al. (2016) Visualizing mechanical modulation of nanoscale organization of cell-matrix adhesions. Integr Biol (Camb) 8:795-804 |
| Kai, FuiBoon; Laklai, Hanane; Weaver, Valerie M (2016) Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease. Trends Cell Biol 26:486-497 |
Showing the most recent 10 out of 47 publications
