Public Health Relevance

Breast cancer screening detects many early stage breast cancers (ductal carcinoma in situ or ''DCIS'') that are unlikely to threaten a woman's life. However; aggressive treatment is recommended for all women with DCIS because we cannot currently identify which of these DCIS cases are potentially life threatening. Our research is focused on finding ways to know which DCIS cases are unlikely to progress to invasive cancer so that these women do not have to suffer needlessly from the side effects of aggressive treatment.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54CA163303-01
Application #
8567640
Study Section
Special Emphasis Panel (ZCA1-SRLB-R (O1))
Project Start
2011-09-23
Project End
2016-08-31
Budget Start
2011-09-23
Budget End
2012-08-31
Support Year
1
Fiscal Year
2011
Total Cost
$546,473
Indirect Cost
Name
University of Vermont & St Agric College
Department
Type
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
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Sprague, Brian L; Vacek, Pamela M; Herschorn, Sally D et al. (2018) Time-varying risks of second events following a DCIS diagnosis in the population-based Vermont DCIS cohort. Breast Cancer Res Treat :
Plevritis, Sylvia K; Munoz, Diego; Kurian, Allison W et al. (2018) Association of Screening and Treatment With Breast Cancer Mortality by Molecular Subtype in US Women, 2000-2012. JAMA 319:154-164
Trentham-Dietz, Amy; Ergun, Mehmet Ali; Alagoz, Oguzhan et al. (2018) Comparative effectiveness of incorporating a hypothetical DCIS prognostic marker into breast cancer screening. Breast Cancer Res Treat 168:229-239
Conklin, Matthew W; Gangnon, Ronald E; Sprague, Brian L et al. (2018) Collagen Alignment as a Predictor of Recurrence after Ductal Carcinoma In Situ. Cancer Epidemiol Biomarkers Prev 27:138-145

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