Abstract

Diffusion tensor imaging can measure the microstructural integrity and orientational structure of nerve tissue. Computational tools to extract microstructural information from DTI will enhance insight into neuroanatomy, neuropathology, and neuropsychiatric disorders. We propose to develop statistical tools to test group-level hypotheses on white matter histoarchitecture based on diffusion imaging. We will extend analytic and statistical tools developed for scalar data, to orientational diffusion data, leading to improved registration, segmentation, and analysis of tissue microstructure.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54EB005149-04
Application #
7479769
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2007-08-01
Budget End
2008-07-31
Support Year
4
Fiscal Year
2007
Total Cost
$314,294
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Ghayoor, Ali; Vaidya, Jatin G; Johnson, Hans J (2018) Robust automated constellation-based landmark detection in human brain imaging. Neuroimage 170:471-481
Wachinger, Christian; Toews, Matthew; Langs, Georg et al. (2018) Keypoint Transfer for Fast Whole-Body Segmentation. IEEE Trans Med Imaging :
Lyu, Ilwoo; Perdomo, Jonathan; Yapuncich, Gabriel S et al. (2018) Group-wise Shape Correspondence of Variable and Complex Objects. Proc SPIE Int Soc Opt Eng 10574:
Hong, Sungmin; Fishbaugh, James; Gerig, Guido (2018) 4D CONTINUOUS MEDIAL REPRESENTATION BY GEODESIC SHAPE REGRESSION. Proc IEEE Int Symp Biomed Imaging 2018:1014-1017
Swanson, Meghan R; Wolff, Jason J; Shen, Mark D et al. (2018) Development of White Matter Circuitry in Infants With Fragile X Syndrome. JAMA Psychiatry 75:505-513
Swanson, Meghan R; Shen, Mark D; Wolff, Jason J et al. (2018) Naturalistic Language Recordings Reveal ""Hypervocal"" Infants at High Familial Risk for Autism. Child Dev 89:e60-e73
Swanson, Meghan R; Shen, Mark D; Wolff, Jason J et al. (2017) Subcortical Brain and Behavior Phenotypes Differentiate Infants With Autism Versus Language Delay. Biol Psychiatry Cogn Neurosci Neuroimaging 2:664-672
Veni, Gopalkrishna; Elhabian, Shireen Y; Whitaker, Ross T (2017) ShapeCut: Bayesian surface estimation using shape-driven graph. Med Image Anal 40:11-29
Irimia, Andrei; Goh, Sheng-Yang Matthew; Wade, Adam C et al. (2017) Traumatic Brain Injury Severity, Neuropathophysiology, and Clinical Outcome: Insights from Multimodal Neuroimaging. Front Neurol 8:530
Rutherford, Helena J V; Maupin, Angela N; Landi, Nicole et al. (2017) Parental reflective functioning and the neural correlates of processing infant affective cues. Soc Neurosci 12:519-529

Showing the most recent 10 out of 668 publications