Abstract

This schematic illustrates the organization of the Chemical Biodefense Group which is a collaborative group of the National Jewish Medical and Research Center and the University of Colorado at Denver Health Sciences Center. The Administrative Core is headed by Carl W. White, M.D., with Gabriele Cheatham as Administrative Assistant. The Educational Core will provide an annual day-long workshop for health care professionals, biomedical researchers, trainees and students on the topic of chemical biodefense, along with 2- 3 Distinguished Professors annually who will lecture on this or closely aligned research areas. The scientific efforts of the group are contained in three basic and translational projects (Projects 1, 2, and 3) and an Exposure Core. The focus of the group's research is sulfur mustard toxicity in the lung and skin. The model compound 2-chloroethyl-ethyl sulfide (CEES;""""""""half-mustard,"""""""" a less toxic analog of sulfur mustard) will be used in the studies proposed here.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
3U54ES015678-05S1
Application #
8147405
Study Section
Special Emphasis Panel (ZNS1-SRB-R (23))
Program Officer
Shaughnessy, Daniel
Project Start
2006-09-29
Project End
2011-08-22
Budget Start
2010-09-24
Budget End
2011-08-22
Support Year
5
Fiscal Year
2010
Total Cost
$197,794
Indirect Cost

  Institution

Name
National Jewish Health
Department
Type
DUNS #
076443019
City
Denver
State
CO
Country
United States
Zip Code
80206

  Publications

Rancourt, Raymond C; Rioux, Jacqueline S; Veress, Livia A et al. (2018) Methyl isocyanate inhalation induces tissue factor-dependent activation of coagulation in rats. Drug Chem Toxicol :1-7
McGraw, Matthew D; Osborne, Christopher M; Mastej, Emily J et al. (2017) Editor's Highlight: Pulmonary Vascular Thrombosis in Rats Exposed to Inhaled Sulfur Mustard. Toxicol Sci 159:461-469
Summerhill, Eleanor M; Hoyle, Gary W; Jordt, Sven-Eric et al. (2017) An Official American Thoracic Society Workshop Report: Chemical Inhalational Disasters. Biology of Lung Injury, Development of Novel Therapeutics, and Medical Preparedness. Ann Am Thorac Soc 14:1060-1072
Ghosh, Moumita; Ahmad, Shama; White, Carl W et al. (2017) Transplantation of Airway Epithelial Stem/Progenitor Cells: A Future for Cell-Based Therapy. Am J Respir Cell Mol Biol 56:1-10
McElroy, Cameron S; Min, Elysia; Huang, Jie et al. (2016) From the Cover: Catalytic Antioxidant Rescue of Inhaled Sulfur Mustard Toxicity. Toxicol Sci 154:341-353
White, Carl W; Rancourt, Raymond C; Veress, Livia A (2016) Sulfur mustard inhalation: mechanisms of injury, alteration of coagulation, and fibrinolytic therapy. Ann N Y Acad Sci 1378:87-95
Tewari-Singh, Neera; Agarwal, Rajesh (2016) Mustard vesicating agent-induced toxicity in the skin tissue and silibinin as a potential countermeasure. Ann N Y Acad Sci 1374:184-92
McElroy, Cameron S; Day, Brian J (2016) Antioxidants as potential medical countermeasures for chemical warfare agents and toxic industrial chemicals. Biochem Pharmacol 100:1-11
Houin, Paul R; Veress, Livia A; Rancourt, Raymond C et al. (2015) Intratracheal heparin improves plastic bronchitis due to sulfur mustard analog. Pediatr Pulmonol 50:118-26
Veress, Livia A; Anderson, Dana R; Hendry-Hofer, Tara B et al. (2015) Airway tissue plasminogen activator prevents acute mortality due to lethal sulfur mustard inhalation. Toxicol Sci 143:178-84

Showing the most recent 10 out of 58 publications