Abstract

Protein-carbohydrate interactions are now recognized to be important mediators of cell communication. In the last decade many novel carbohydrate binding receptors (CBPs) have been described, several of which have been documented to play critical roles in cell trafficking and cell signaling. Despite these advances the rate at which new information has been generated has been slow, and the biological roles of most mammalian carbohydrate binding proteins are poorly understood. While the importance of this field has attracted many outstanding laboratories, a major barrier to progress has been the additional complexity of the carbohydrates themselves and the analytical and synthetic challenges they pose. The overarching goal of this project is to define the biochemical mechanisms by which protein-carbohydrate interactions mediate cellular events. The project brings together a international multi-institutional and multi-disciplinary group of participating investigators that have a common goal of elucidating the roles of carbohydrate binding proteins in cell communication. Their combined expertise, aided by core resources that are currently unavailable, will dramatically accelerate progress in this emerging frontier.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54GM062116-03
Application #
6653921
Study Section
Special Emphasis Panel (ZGM1-BT-1 (01))
Program Officer
Marino, Pamela
Project Start
2001-09-30
Project End
2006-08-31
Budget Start
2003-09-01
Budget End
2004-08-31
Support Year
3
Fiscal Year
2003
Total Cost
$7,664,787
Indirect Cost

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Peng, Wenjie; Bouwman, Kim M; McBride, Ryan et al. (2018) Enhanced Human-Type Receptor Binding by Ferret-Transmissible H5N1 with a K193T Mutation. J Virol 92:
Sadana, Pooja; Geyer, Rebecca; Pezoldt, Joern et al. (2018) The invasin D protein from Yersinia pseudotuberculosis selectively binds the Fab region of host antibodies and affects colonization of the intestine. J Biol Chem 293:8672-8690
Nemanichvili, Nikoloz; Tomris, Ilhan; Turner, Hannah L et al. (2018) Fluorescent Trimeric Hemagglutinins Reveal Multivalent Receptor Binding Properties. J Mol Biol :
Yang, Hua; Carney, Paul J; Chang, Jessie C et al. (2018) Structural and Molecular Characterization of the Hemagglutinin from the Fifth Epidemic Wave A(H7N9) Influenza Viruses. J Virol :
van Eijk, Martin; Rynkiewicz, Michael J; Khatri, Kshitij et al. (2018) Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus. J Biol Chem 293:10646-10662
Griffiths, James S; Thompson, Aiysha; Stott, Matthew et al. (2018) Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases. FASEB J 32:3385-3397
Littler, Dene R; Ang, Sheng Y; Moriel, Danilo G et al. (2017) Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins. J Biol Chem 292:15143-15158
Sun, Hailiang; Kaplan, Bryan S; Guan, Minhui et al. (2017) Pathogenicity and transmission of a swine influenza A(H6N6) virus. Emerg Microbes Infect 6:e17
Polonskaya, Zinaida; Deng, Shenglou; Sarkar, Anita et al. (2017) T cells control the generation of nanomolar-affinity anti-glycan antibodies. J Clin Invest 127:1491-1504
Peng, Wenjie; de Vries, Robert P; Grant, Oliver C et al. (2017) Recent H3N2 Viruses Have Evolved Specificity for Extended, Branched Human-type Receptors, Conferring Potential for Increased Avidity. Cell Host Microbe 21:23-34

Showing the most recent 10 out of 444 publications