Abstract

Public Health Relevance

Transporters are vital to the biology of all cells and a variety of diseases occur when these processes are perturbed or disrupted, as in several genetic disorders or the up-regulation of multidrug resistance transporters by tumor cells. The development of effective therapeutics for the treatment of transport related diseases will be greatly accelerated by the availability of high resolution structures of human transporters, which are essential to understand the molecular structural basis of their mechanisms in detail.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54GM094610-01
Application #
8152828
Study Section
Special Emphasis Panel (ZGM1-CBB-3 (MP))
Project Start
2010-09-30
Project End
2015-06-30
Budget Start
2010-09-30
Budget End
2011-06-30
Support Year
1
Fiscal Year
2010
Total Cost
$819,394
Indirect Cost

  Institution

Name
California Institute of Technology
Department
Type
DUNS #
009584210
City
Pasadena
State
CA
Country
United States
Zip Code
91125

  Publications

Vastermark, Ake; Driker, Adelle; Weng, Jingwei et al. (2017) Difference distance map data of alternative crystal forms of UlaA. Data Brief 10:198-201
He, Xiao; Garza, Denisse; Nigam, Sanjay K et al. (2016) Multispecific Organic Cation Transporter 1 (OCT1) from Bos taurus Has High Affinity and Slow Binding Kinetics towards Prostaglandin E2. PLoS One 11:e0152969
Saier Jr, Milton H (2016) Transport protein evolution deduced from analysis of sequence, topology and structure. Curr Opin Struct Biol 38:9-17
Vastermark, Ake; Driker, Adelle; Weng, Jingwei et al. (2016) The V-motifs facilitate the substrate capturing step of the PTS elevator mechanism. J Struct Biol 196:496-502
Moeller, Arne; Lee, Sung Chang; Tao, Houchao et al. (2015) Distinct conformational spectrum of homologous multidrug ABC transporters. Structure 23:450-460
Saier Jr, Milton H (2015) The Bacterial Phosphotransferase System: New Frontiers 50 Years after Its Discovery. J Mol Microbiol Biotechnol 25:73-8
Hildebrandt, Ellen; Mulky, Alok; Ding, Haitao et al. (2015) A stable human-cell system overexpressing cystic fibrosis transmembrane conductance regulator recombinant protein at the cell surface. Mol Biotechnol 57:391-405
Västermark, Åke; Driker, Adelle; Li, Jiaqi et al. (2015) Conserved movement of TMS11 between occluded conformations of LacY and XylE of the major facilitator superfamily suggests a similar hinge-like mechanism. Proteins 83:735-45
Babbitt, Patricia C; Bagos, Pantelis G; Bairoch, Amos et al. (2015) Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat. Database (Oxford) 2015:bav063
Västermark, Ake; Lunt, Bryan; Saier, Milton (2014) Major facilitator superfamily porters, LacY, FucP and XylE of Escherichia coli appear to have evolved positionally dissimilar catalytic residues without rearrangement of 3-TMS repeat units. J Mol Microbiol Biotechnol 24:82-90

Showing the most recent 10 out of 21 publications