Proteins embedded in membranes are abundant (20-30% of proteins in any organism) and they perform some of the most essential of activities in biology. Their importance for biomedicine is evident as they are the molecular targets of more than 40% of all FDA-approved drugs. Yet, because membrane proteins present severe challenges for biophysical study, membrane proteins currently constitute less than 1% of known atomic-level structures.
Assur Sanghai, Zahra; Liu, Qun; Clarke, Oliver B et al. (2018) Structure-based analysis of CysZ-mediated cellular uptake of sulfate. Elife 7: |
Su, Min; Gao, Feng; Yuan, Qi et al. (2017) Structural basis for conductance through TRIC cation channels. Nat Commun 8:15103 |
Dufrisne, Meagan Belcher; Petrou, Vasileios I; Clarke, Oliver B et al. (2017) Structural basis for catalysis at the membrane-water interface. Biochim Biophys Acta Mol Cell Biol Lipids 1862:1368-1385 |
Scaglione, Antonella; Montemiglio, Linda Celeste; Parisi, Giacomo et al. (2017) Subcellular localization of the five members of the human steroid 5?-reductase family. Biochim Open 4:99-106 |
Petrou, Vasileios I; Herrera, Carmen M; Schultz, Kathryn M et al. (2016) Structures of aminoarabinose transferase ArnT suggest a molecular basis for lipid A glycosylation. Science 351:608-12 |
Ardiccioni, Chiara; Clarke, Oliver B; Tomasek, David et al. (2016) Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis. Nat Commun 7:10175 |
Kalathur, Ravi C; Panganiban, Marinela; Bruni, Renato (2016) High-Throughput Baculovirus Expression System for Membrane Protein Production. Methods Mol Biol 1432:187-202 |
Bernhofer, Michael; Kloppmann, Edda; Reeb, Jonas et al. (2016) TMSEG: Novel prediction of transmembrane helices. Proteins 84:1706-1716 |
McCoy, Jason G; Ren, Zhenning; Stanevich, Vitali et al. (2016) The Structure of a Sugar Transporter of the Glucose EIIC Superfamily Provides Insight into the Elevator Mechanism of Membrane Transport. Structure 24:956-64 |
Hendrickson, Wayne A (2016) Atomic-level analysis of membrane-protein structure. Nat Struct Mol Biol 23:464-7 |
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