Abstract

The objectives of this Core are to provide resources to the Center for studies of contraceptive targets in humans and non-human primates and for testing the effectiveness of contraceptive agents in primates. Specifically, the objectives of the Core are: 1. To provide the organizational structure and expertise required for application of concepts and products from basic research in Center Projects to human contraceptive development. 2. To provide a laboratory resource for biochemical and molecular biology studies to identify human and non-humanprimate homologs of contraceptive targets identified by Center Projects in the mouse model. 3. To provide an animal resource of non-human primates for preliminary testing of the safety of contraceptive agents and methods for their delivery. 4. To provide biological materials including tissues, body fluids and gametes from humans and non-human primates for in vitro assays of contraceptive actions. 5. To provide the facilities and expertise required for large-scale breeding studies with non-human primates to determine the efficacy and safety of contraceptive agents.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
3U54HD029125-11S1
Application #
6577263
Study Section
Project Start
2001-03-01
Project End
2002-06-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
11
Fiscal Year
2002
Total Cost
$165,579
Indirect Cost

  Institution

Name
University of California Davis
Department
Type
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Sutton, Keith A; Jungnickel, Melissa K; Ward, Christopher J et al. (2006) Functional characterization of PKDREJ, a male germ cell-restricted polycystin. J Cell Physiol 209:493-500
Yu, Junying; Deng, Manqi; Medvedev, Sergey et al. (2004) Transgenic RNAi-mediated reduction of MSY2 in mouse oocytes results in reduced fertility. Dev Biol 268:195-206
Yu, Junying; Hecht, Norman B; Schultz, Richard M (2003) Requirement for RNA-binding activity of MSY2 for cytoplasmic localization and retention in mouse oocytes. Dev Biol 255:249-62
Talbot, Prudence; Shur, Barry D; Myles, Diana G (2003) Cell adhesion and fertilization: steps in oocyte transport, sperm-zona pellucida interactions, and sperm-egg fusion. Biol Reprod 68:1-9
Miller, Christopher J; Lu, Fabien X (2003) Anti-HIV and -SIV immunity in the vagina. Int Rev Immunol 22:65-76
Tollner, Theodore L; Yudin, Ashley I; Cherr, Gary N et al. (2003) Real-time observations of individual macaque sperm undergoing tight binding and the acrosome reaction on the zona pellucida. Biol Reprod 68:664-72
Tollner, T L; Overstreet, J W; Branciforte, D et al. (2002) Immunization of female cynomolgus macaques with a synthetic epitope of sperm-specific lactate dehydrogenase results in high antibody titers but does not reduce fertility. Mol Reprod Dev 62:257-64
Deng, X; Meyers, S A; Tollner, T L et al. (2002) Immunological response of female macaques to the PH-20 sperm protein following injection of recombinant proteins or synthesized peptides. J Reprod Immunol 54:93-115
Li, Ming-Wen; Yudin, Ashley I; Robertson, Kathryn R et al. (2002) Importance of glycosylation and disulfide bonds in hyaluronidase activity of macaque sperm surface PH-20. J Androl 23:211-9
Primakoff, Paul; Myles, Diana G (2002) Penetration, adhesion, and fusion in mammalian sperm-egg interaction. Science 296:2183-5

Showing the most recent 10 out of 61 publications