Abstract

CLINICAL TRANSLATIONAL CORE (CORE B) ABSTRACT The objectives of the new Clinical Translational Core of our IDDRC are to accelerate the translation of research discoveries into new treatments for neurodevelopmental disorders, through collaboration with basic scientists and clinicians, as well as to train future leaders in translational neuroscience. Resources offered by the Clinical Translational Core include preclinical support through a Human Neuron Core Component, composed of a Cellular Assay Development and Screening Service and a Human Neuron Differentiation Service. Additionally, support for translational work includes resources through a Clinical and Regulatory Affairs Service, a Data Analysis Core Component, Biorepository and preclinical consultation. The core has a proven record of success in designing and launching preclinical and clinical projects for IDDRC investigators.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54HD090255-01
Application #
9229203
Study Section
Special Emphasis Panel (ZHD1-DSR-H (50))
Project Start
2016-09-23
Project End
2021-05-31
Budget Start
2016-09-01
Budget End
2017-05-31
Support Year
1
Fiscal Year
2016
Total Cost
$143,952
Indirect Cost
$62,623

  Institution

Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Joyal, Jean-Sébastien; Gantner, Marin L; Smith, Lois E H (2018) Retinal energy demands control vascular supply of the retina in development and disease: The role of neuronal lipid and glucose metabolism. Prog Retin Eye Res 64:131-156
Zhang, Fan; Wu, Weining; Ning, Lipeng et al. (2018) Suprathreshold fiber cluster statistics: Leveraging white matter geometry to enhance tractography statistical analysis. Neuroimage 171:341-354
Damar, Ugur; Gersner, Roman; Johnstone, Joshua T et al. (2018) Alterations in the Timing of Huperzine A Cerebral Pharmacodynamics in the Acute Traumatic Brain Injury Setting. J Neurotrauma 35:393-397
Joureau, Barbara; de Winter, Josine Marieke; Conijn, Stefan et al. (2018) Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1-related nemaline myopathy (NEM3). Ann Neurol 83:269-282
Ordonez, Dalila G; Lee, Michael K; Feany, Mel B (2018) ?-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton. Neuron 97:108-124.e6
Blake, Kimbria J; Baral, Pankaj; Voisin, Tiphaine et al. (2018) Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314. Nat Commun 9:37
Bichsel, Colette A; Goss, Jeremy; Alomari, Mohammed et al. (2018) Association of Somatic GNAQ Mutation With Capillary Malformations in a Case of Choroidal Hemangioma. JAMA Ophthalmol :
Kelly, Elyza; Schaeffer, Samantha M; Dhamne, Sameer C et al. (2018) mGluR5 Modulation of Behavioral and Epileptic Phenotypes in a Mouse Model of Tuberous Sclerosis Complex. Neuropsychopharmacology 43:1457-1465
Pena, Loren D M; Jiang, Yong-Hui; Schoch, Kelly et al. (2018) Looking beyond the exome: a phenotype-first approach to molecular diagnostic resolution in rare and undiagnosed diseases. Genet Med 20:464-469
Ley, David; Hallberg, Boubou; Hansen-Pupp, Ingrid et al. (2018) rhIGF-1/rhIGFBP-3 in Preterm Infants: A Phase 2 Randomized Controlled Trial. J Pediatr :

Showing the most recent 10 out of 498 publications