Under NHGRI's sequencing pilot project, the Whitehead/MIT Center for Genome Research has developed a scalable and efficient process for genomic sequencing.
The specific aim of this proposal is to convert our pilot project to a production center by: (i) increasing lane capacity to 20 M lanes per year, by expanding our automated systems for sample prep and purchasing a fleet of capillary sequencers; and (ii) achieving a production rate of finished sequence of at least 750 Mb per year at a cost of 10 cents/base including overhead. We are also committed to working closely with NHGRI and other centers to adapt to rapidly changing circumstances, to ensure the overall rapid success of the Human Genome Project.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
3U54HG002045-04S2
Application #
6664138
Study Section
Special Emphasis Panel (ZHG1 (J2))
Program Officer
Peterson, Jane
Project Start
1999-03-08
Project End
2003-10-31
Budget Start
2002-09-30
Budget End
2002-10-31
Support Year
4
Fiscal Year
2002
Total Cost
$589,825
Indirect Cost
Name
Whitehead Institute for Biomedical Research
Department
Type
DUNS #
076580745
City
Cambridge
State
MA
Country
United States
Zip Code
02142
Brawand, David; Wagner, Catherine E; Li, Yang I et al. (2014) The genomic substrate for adaptive radiation in African cichlid fish. Nature 513:375-381
Park, Sung-Sup; Stankiewicz, Pawel; Bi, Weimin et al. (2002) Structure and evolution of the Smith-Magenis syndrome repeat gene clusters, SMS-REPs. Genome Res 12:729-38