Abstract

B. Assay Development and Adaptation CoreThe assay development and adaptation core will be responsible for the development and evaluation ofphysiologically relevant and disease-related assays, adaptation of these assays for automated HTS and HCS,and guidance to collaborators for further assay development. This includes the development and implementationof physiologically relevant counter screens and secondary assays.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54HG005032-01
Application #
7695855
Study Section
Special Emphasis Panel (ZRG1-IFCN-K (52))
Project Start
2008-09-01
Project End
2014-05-31
Budget Start
2008-09-01
Budget End
2009-05-31
Support Year
1
Fiscal Year
2008
Total Cost
$1,899,382
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

McLellan, Catherine A; Vincent, Benjamin M; Solis, Norma V et al. (2018) Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy. Nat Chem Biol 14:135-141
Sharabi, Kfir; Lin, Hua; Tavares, Clint D J et al. (2017) Selective Chemical Inhibition of PGC-1? Gluconeogenic Activity Ameliorates Type 2 Diabetes. Cell 169:148-160.e15
Lessing, Derek; Dial, Thomas O; Wei, Chunyao et al. (2016) A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation. Proc Natl Acad Sci U S A 113:14366-14371
Lewis, Timothy A; Sykes, David B; Law, Jason M et al. (2016) Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett 7:1112-1117
Lopez-Sambrooks, Cecilia; Shrimal, Shiteshu; Khodier, Carol et al. (2016) Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat Chem Biol 12:1023-1030
Bekendam, Roelof H; Bendapudi, Pavan K; Lin, Lin et al. (2016) A substrate-driven allosteric switch that enhances PDI catalytic activity. Nat Commun 7:12579
Sykes, David B; Kfoury, Youmna S; Mercier, François E et al. (2016) Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell 167:171-186.e15
Wagner, Florence F; Bishop, Joshua A; Gale, Jennifer P et al. (2016) Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. ACS Chem Biol 11:1952-63
Zielonka, Jacek; Zielonka, Monika; VerPlank, Lynn et al. (2016) Mitigation of NADPH Oxidase 2 Activity as a Strategy to Inhibit Peroxynitrite Formation. J Biol Chem 291:7029-44
de Waal, Luc; Lewis, Timothy A; Rees, Matthew G et al. (2016) Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics. Nat Chem Biol 12:102-8

Showing the most recent 10 out of 46 publications