Abstract

The goals of the Core A, the Administrative Core are to provide leadership for all components of theBoston Comprehensive Sickle Cell Center (BCSCC) by interacting with its component cores,investigators and their research projects, the NHLBI Project Scientist, administration and sponsoredresearch offices of participating institutions and the Steering Committee of the Comprehensive SickleCell Centers (CSCC) program. Core A will also: manage the financial affairs of the BCSCC; arrangeand conduct meetings of center investigators to encourage their interaction; provide for continuedinternal and external evaluation of progress.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
2U54HL070819-06
Application #
7458483
Study Section
Special Emphasis Panel (ZHL1-CSR-O (F1))
Project Start
2008-06-18
Project End
2012-03-31
Budget Start
2008-06-18
Budget End
2009-03-31
Support Year
6
Fiscal Year
2008
Total Cost
$116,369
Indirect Cost

  Institution

Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Maron, Bradley A; Oldham, William M; Chan, Stephen Y et al. (2014) Upregulation of steroidogenic acute regulatory protein by hypoxia stimulates aldosterone synthesis in pulmonary artery endothelial cells to promote pulmonary vascular fibrosis. Circulation 130:168-79
Cottrill, Katherine A; Chan, Stephen Y; Loscalzo, Joseph (2014) Hypoxamirs and mitochondrial metabolism. Antioxid Redox Signal 21:1189-201
Loscalzo, Joseph; Handy, Diane E (2014) Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series). Pulm Circ 4:169-74
Zhao, Yuzheng; Yang, Yi; Loscalzo, Joseph (2014) Real-time assessment of the metabolic profile of living cells with genetically encoded NADH sensors. Methods Enzymol 542:349-67
Barroso, Madalena; Florindo, Cristina; Kalwa, Hermann et al. (2014) Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression. J Biol Chem 289:15350-62
Joseph, Jacob; Loscalzo, Joseph (2013) Selenistasis: epistatic effects of selenium on cardiovascular phenotype. Nutrients 5:340-58
Maron, Bradley A; Tang, Shiow-Shih; Loscalzo, Joseph (2013) S-nitrosothiols and the S-nitrosoproteome of the cardiovascular system. Antioxid Redox Signal 18:270-87
Maron, Bradley A; Waxman, Aaron B; Opotowsky, Alexander R et al. (2013) Effectiveness of spironolactone plus ambrisentan for treatment of pulmonary arterial hypertension (from the [ARIES] study 1 and 2 trials). Am J Cardiol 112:720-5
Handy, Diane E; Loscalzo, Joseph; Leopold, Jane A (2013) Systems analysis of oxidant stress in the vasculature. IUBMB Life 65:911-20
Nallamshetty, Shriram; Chan, Stephen Y; Loscalzo, Joseph (2013) Hypoxia: a master regulator of microRNA biogenesis and activity. Free Radic Biol Med 64:20-30

Showing the most recent 10 out of 82 publications