We plan for the next Sickle Cell Scholar to provide protected time and the resources necessary for a young investigator or investigator new to the field to pursue original research relevant to understanding the genetics, pathophysiology, psychology or treatment of sickle cell disease. To facilitate this we will provide an experienced mentor capable of guiding this work to a successful conclusion, encourage productive interactions between the Scholar, other members of the Boston Comprehensive Sickle Cell Center (BCSCC) and sickle cell disease investigators throughout the nation and provide an infrastructure to allow the Sickle Cell Scholar ultimately to pursue a career of peer-reviewed independent research

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HL070819-07
Application #
7828051
Study Section
Special Emphasis Panel (ZHL1)
Project Start
2009-05-04
Project End
2012-03-31
Budget Start
2009-05-04
Budget End
2010-03-31
Support Year
7
Fiscal Year
2009
Total Cost
$186,509
Indirect Cost
Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118
Maron, Bradley A; Oldham, William M; Chan, Stephen Y et al. (2014) Upregulation of steroidogenic acute regulatory protein by hypoxia stimulates aldosterone synthesis in pulmonary artery endothelial cells to promote pulmonary vascular fibrosis. Circulation 130:168-79
Cottrill, Katherine A; Chan, Stephen Y; Loscalzo, Joseph (2014) Hypoxamirs and mitochondrial metabolism. Antioxid Redox Signal 21:1189-201
Loscalzo, Joseph; Handy, Diane E (2014) Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series). Pulm Circ 4:169-74
Zhao, Yuzheng; Yang, Yi; Loscalzo, Joseph (2014) Real-time assessment of the metabolic profile of living cells with genetically encoded NADH sensors. Methods Enzymol 542:349-67
Barroso, Madalena; Florindo, Cristina; Kalwa, Hermann et al. (2014) Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression. J Biol Chem 289:15350-62
Maron, Bradley A; Waxman, Aaron B; Opotowsky, Alexander R et al. (2013) Effectiveness of spironolactone plus ambrisentan for treatment of pulmonary arterial hypertension (from the [ARIES] study 1 and 2 trials). Am J Cardiol 112:720-5
Handy, Diane E; Loscalzo, Joseph; Leopold, Jane A (2013) Systems analysis of oxidant stress in the vasculature. IUBMB Life 65:911-20
Nallamshetty, Shriram; Chan, Stephen Y; Loscalzo, Joseph (2013) Hypoxia: a master regulator of microRNA biogenesis and activity. Free Radic Biol Med 64:20-30
Silverman, E K; Loscalzo, J (2013) Developing new drug treatments in the era of network medicine. Clin Pharmacol Ther 93:26-8
Kao, Derrick D; Oldebeken, Scott R; Rai, Anjali et al. (2013) Tumor necrosis factor-?-mediated suppression of dual-specificity phosphatase 4: crosstalk between NF?B and MAPK regulates endothelial cell survival. Mol Cell Biochem 382:153-62

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