Abstract

The Sickle Cell Scholar training program is an integral part of the education component of theComprehensive Sickle Cell Center grant. The Sickle Cell Scholar will be chosen according to the guidelinesin the RFA. Under the auspices of the Los Angeles Sickle Cell Center, the scholar will have the opportunityto do clinical and translational research related to the efficacy of L-glutamine in ameliorating the symptoms ofsickle cell disease, the genesis of cardiac dysfunction in transfused sickle cell patients, the health servicesresearch related to provision of adult care, or translational research related to the role of viscosity inalteration of blood flow and oxygen delivery in humans and the use of engineering techniques to detectevidence of sickling.Unique to this program, the scholar will be supervised by the Center education director who is a cell biologistand doctoral level educator. This individual will be responsible for setting educational milestones andsystematically monitoring the progress of the scholar to the training program.Also described here is a plan for the management of the summer high school student program that will alsobe run by the Center education director.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54HL090511-01
Application #
7458368
Study Section
Special Emphasis Panel (ZHL1-CSR-O (F1))
Project Start
2008-06-15
Project End
2012-03-31
Budget Start
2008-06-15
Budget End
2009-03-31
Support Year
1
Fiscal Year
2008
Total Cost
$165,375
Indirect Cost

  Institution

Name
Children's Hospital of Los Angeles
Department
Type
DUNS #
052277936
City
Los Angeles
State
CA
Country
United States
Zip Code
90027

  Publications

Detterich, Jon A; Kato, Roberta M; Rabai, Miklos et al. (2015) Chronic transfusion therapy improves but does not normalize systemic and pulmonary vasculopathy in sickle cell disease. Blood 126:703-10
Rabai, Miklos; Detterich, Jon A; Wenby, Rosalinda B et al. (2014) Deformability analysis of sickle blood using ektacytometry. Biorheology 51:159-70
Sonmez, Melda; Ince, Huseyin Yavuz; Yalcin, Ozlem et al. (2013) The effect of alcohols on red blood cell mechanical properties and membrane fluidity depends on their molecular size. PLoS One 8:e76579
Meram, Ece; Yilmaz, Bahar D; Bas, Ceren et al. (2013) Shear stress-induced improvement of red blood cell deformability. Biorheology 50:165-76
Baskurt, Oguz K; Meiselman, Herbert J (2013) Red blood cell mechanical stability test. Clin Hemorheol Microcirc 55:55-62
Meloni, Antonella; Rienhoff Jr, Hugh Y; Jones, Amber et al. (2013) The use of appropriate calibration curves corrects for systematic differences in liver R2* values measured using different software packages. Br J Haematol 161:888-91
Ulker, Pinar; Gunduz, Filiz; Meiselman, Herbert J et al. (2013) Nitric oxide generated by red blood cells following exposure to shear stress dilates isolated small mesenteric arteries under hypoxic conditions. Clin Hemorheol Microcirc 54:357-69
Detterich, Jon A; Sangkatumvong, Suvimol; Kato, Roberta et al. (2013) Patients with sickle cell anemia on simple chronic transfusion protocol show sex differences for hemodynamic and hematologic responses to transfusion. Transfusion 53:1059-68
Detterich, Jon; Alexy, Tamas; Rabai, Miklos et al. (2013) Low-shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy. Transfusion 53:297-305
Sangkatumvong, Suvimol; Khoo, Michael C K; Kato, Roberta et al. (2011) Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease. Am J Respir Crit Care Med 184:474-81

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