Abstract

The mouse is the most commonly used animal in biomedical research comprising >90% of all animal experimentation. This mammalian species is often the prime choice to flesh out mechanisms of action of drugs and to establish biochemical signaling pathways prior to entering human trials. Directly relevant to PENTACON, mice were used to predict and then assign mechanistic understanding to all recognized features ? thrombosis, hypertension, heart failure, dysrhythmia ? of the cardiovascular hazard in humans taking COX-2 selective NSAIDs (1,2). More than 20 genetic mouse models that disrupt or perturb the COX biosyntheticresponse pathway have been developed by PENTACON members, a unique resource for use in this proposal.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54HL117798-01
Application #
8126768
Study Section
Special Emphasis Panel (ZGM1-PPBC-0 (GL))
Project Start
2012-08-01
Project End
2017-05-31
Budget Start
2012-08-01
Budget End
2013-05-31
Support Year
1
Fiscal Year
2012
Total Cost
$311,358
Indirect Cost
$70,306

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Hao, Huifeng; Hu, Sheng; Wan, Qing et al. (2018) Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)-Derived PGE2 (Prostaglandin E2) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury. Arterioscler Thromb Vasc Biol 38:1115-1124
Mazaleuskaya, Liudmila L; Salamatipour, Ashkan; Sarantopoulou, Dimitra et al. (2018) Analysis of HETEs in human whole blood by chiral UHPLC-ECAPCI/HRMS. J Lipid Res 59:564-575
Chen, Lihong; Yang, Guangrui; Zhang, Jiayang et al. (2018) Time-Dependent Hypotensive Effect of Aspirin in Mice. Arterioscler Thromb Vasc Biol 38:2819-2826
Song, Wen-Liang; Ricciotti, Emanuela; Liang, Xue et al. (2018) Lipocalin-Like Prostaglandin D Synthase but Not Hemopoietic Prostaglandin D Synthase Deletion Causes Hypertension and Accelerates Thrombogenesis in Mice. J Pharmacol Exp Ther 367:425-432
Wang, Dandan; Hu, Xiaoyue; Lee, Seung Hee et al. (2018) Diabetes Exacerbates Myocardial Ischemia/Reperfusion Injury by Down-Regulation of MicroRNA and Up-Regulation of O-GlcNAcylation. JACC Basic Transl Sci 3:350-362
Di Giovanni, James P; Barkley, Robert M; Jones, David N M et al. (2018) Tandem Mass Spectrometry and Ion Mobility Reveals Structural Insight into Eicosanoid Product Ion Formation. J Am Soc Mass Spectrom 29:1231-1241
Paschos, Georgios K; Tang, Soon Yew; Theken, Katherine N et al. (2018) Cold-Induced Browning of Inguinal White Adipose Tissue Is Independent of Adipose Tissue Cyclooxygenase-2. Cell Rep 24:809-814
Zhou, Jian; Theesfeld, Chandra L; Yao, Kevin et al. (2018) Deep learning sequence-based ab initio prediction of variant effects on expression and disease risk. Nat Genet 50:1171-1179
Okuno, Toshiaki; Gijón, Miguel A; Zarini, Simona et al. (2018) Altered eicosanoid production and phospholipid remodeling during cell culture. J Lipid Res 59:542-549
Ricciotti, Emanuela; Castro, Cecilia; Tang, Soon Yew et al. (2018) Cyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs. Circulation 138:2367-2378

Showing the most recent 10 out of 91 publications