Abstract

The most innovative aspect of our Pilot Project is to use EMR data to define NSAID usage and CVD outcomes. We will use EMR data to define a large cohort of RA and OA patients. We will create an ondemand registry to target biospecimen collection using discarded tissue from routine care. We have already demonstrated that such an approach is feasible for patients with RA (see Preliminary Data in the Approach Section). We have not yet demonstrated that we can define NSAID usage and CVD outcome with high sensitivity and specificity. If we are indeed able to define precisely NSAID usage and CVD outcome, then we will be in a position to conduct large, well-powered genomic studies later in the funding period.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HL117798-02
Application #
8516105
Study Section
Special Emphasis Panel (ZGM1-PPBC-0)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
2
Fiscal Year
2013
Total Cost
$202,128
Indirect Cost
$59,753

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Ricciotti, Emanuela; Castro, Cecilia; Tang, Soon Yew et al. (2018) Cyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs. Circulation 138:2367-2378
Theken, Katherine N; Grosser, Tilo (2018) Weight-adjusted aspirin for cardiovascular prevention. Lancet 392:361-362
Lin, Nan; Shay, Jessica E S; Xie, Hong et al. (2018) Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis. Front Immunol 9:2565
Li, Xinzhi; Ballantyne, Laurel L; Crawford, Mackenzie C et al. (2018) Isoform-Specific Compensation of Cyclooxygenase (Ptgs) Genes during Implantation and Late-Stage Pregnancy. Sci Rep 8:12097
Ocana, Jesus A; Romer, Eric; Sahu, Ravi et al. (2018) Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms. J Immunol 200:4004-4011
Grosser, Tilo; Naji, Ali; FitzGerald, Garret A (2018) Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment. Circ Res 122:537-539
Liu, Tianyun; Ish-Shalom, Shirbi; Torng, Wen et al. (2018) Biological and functional relevance of CASP predictions. Proteins 86 Suppl 1:374-386
Hao, Huifeng; Hu, Sheng; Wan, Qing et al. (2018) Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)-Derived PGE2 (Prostaglandin E2) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury. Arterioscler Thromb Vasc Biol 38:1115-1124
Mazaleuskaya, Liudmila L; Salamatipour, Ashkan; Sarantopoulou, Dimitra et al. (2018) Analysis of HETEs in human whole blood by chiral UHPLC-ECAPCI/HRMS. J Lipid Res 59:564-575
Chen, Lihong; Yang, Guangrui; Zhang, Jiayang et al. (2018) Time-Dependent Hypotensive Effect of Aspirin in Mice. Arterioscler Thromb Vasc Biol 38:2819-2826

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