The goal of the proposed U54 RCTR grant is to assure that the RMATRIX-II infrastructure supports the further development of the Community of (clinical and translational health disparities) Investigators in Hawaii. Specifically, the aimsare to: (1) Foster clinical and translational health disparities research; (2) Build institutional and community research synergy; and (3) Advance the career development and mentoring of health disparities investigators. Overall, RMATRIX-II will provide an integrated research infrastructure that is connected with various University units, RTRN sites, and the grass-roots community in Hawaii. RMATRIX-II will address these aims as follows:
Specific Aim 1 : RMATRIX-II will provide tools (e.g., pilot projects and integrated research Cores) to foster clinical and translational health disparities research by investigators with skills in basic, clinical and polic research.
Specific Aim 2 : RMATRIX-II will foster collaborations and partnerships among disciplines, departments and/or schools/colleges of UHM, between institutions and with the community.
Specific Aim 3 : RMATRIX-II will foster career development and mentorship using synergistic research cores and a Navigator program to develop junior investigators, especially those with an interest in community based participatory research.

Public Health Relevance

RMATRIX-II will provide the tools needed to build translational research synergy, foster intra- and inter-institutional collaborations and partnerships, and build a Community of Investigators addressing health disparities in Hawaii. Such research infrastructure is invaluable not only for addressing significant existing health disparities, but also for achieving opportunity for the development of skilled investigators from Hawaii.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54MD007584-07
Application #
9261396
Study Section
Special Emphasis Panel (ZMD1)
Program Officer
Berzon, Richard
Project Start
2010-09-16
Project End
2019-04-30
Budget Start
2017-05-01
Budget End
2018-04-30
Support Year
7
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Hawaii
Department
Type
Schools of Medicine
DUNS #
965088057
City
Honolulu
State
HI
Country
United States
Zip Code
96822
D'Antoni, Michelle L; Byron, Mary Margaret; Chan, Phillip et al. (2018) Normalization of Soluble CD163 Levels After Institution of Antiretroviral Therapy During Acute HIV Infection Tracks with Fewer Neurological Abnormalities. J Infect Dis 218:1453-1463
Fang, Rui; Zhu, Yong; Khadka, Vedbar S et al. (2018) The Evaluation of Serum Biomarkers for Non-small Cell Lung Cancer (NSCLC) Diagnosis. Front Physiol 9:1710
Hermosura, Andrea Hepuapo'okela; Haynes, Stephen N; Kaholokula, Joseph Keawe'aimoku (2018) A Preliminary Study of the Relationship between Perceived Racism and Cardiovascular Reactivity and Recovery in Native Hawaiians. J Racial Ethn Health Disparities 5:1142-1154
Aquino, Rachael K; Perez, Michael; Sil, Payel et al. (2018) The Relationship of 5-Aminolevulinic Acid on Mood and Coping Ability in Prediabetic Middle Aged and Older Adults. Geriatrics (Basel) 3:
Palacios, Cristina; Campos, Maribel; Gibby, Cheryl et al. (2018) Effect of a Multi-Site Trial using Short Message Service (SMS) on Infant Feeding Practices and Weight Gain in Low-Income Minorities. J Am Coll Nutr 37:605-613
McElfish, Pearl Anna; Long, Christopher R; Kaholokula, Joseph Keawe'aimoku et al. (2018) Design of a comparative effectiveness randomized controlled trial testing a faith-based Diabetes Prevention Program (WORD DPP) vs. a Pacific culturally adapted Diabetes Prevention Program (PILI DPP) for Marshallese in the United States. Medicine (Baltimore) 97:e0677
Jiang, Zhenhuan; Jiang, Jiannong; Zhao, Bizeng et al. (2018) CPNE1 silencing inhibits the proliferation, invasion and migration of human osteosarcoma cells. Oncol Rep 39:643-650
Pirkle, Catherine M; Wu, Yan Yan; Zunzunegui, Maria-Victoria et al. (2018) Model-based recursive partitioning to identify risk clusters for metabolic syndrome and its components: findings from the International Mobility in Aging Study. BMJ Open 8:e018680
Dou, Yuhong; Zhu, Yong; Ai, Junmei et al. (2018) Plasma small ncRNA pair panels as novel biomarkers for early-stage lung adenocarcinoma screening. BMC Genomics 19:545
Marciel, Michael P; Khadka, Vedbar S; Deng, Youpeng et al. (2018) Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis. Oncotarget 9:13407-13422

Showing the most recent 10 out of 675 publications