The RCMI program provides universally accessible equipment, infrastructure and analysis essential to initiate and sustain research projects at Meharry. In this application, we will address continuity of services and efficiency of resource management by bringing all the supported core equipment and functions into one continuous space, which will be renovated. Therefore, we are also requesting funds to renovate this space. We will accomplish this goal through the following specific aims: 1) Co-localize and merge three independent cores (Molecular Biology, Morphology, Proteomics), and an animal imaging instrument into the research infrastructure core 2) Expand research services and analysis by continuing to support bioinformatics activity, adding health informatics, and increasing biostatistics support 3) Centrally manage the research infrastructure core facility (CRISALIS) to ensure appropriate tracking, billing, and grant attribution by users 4) Cross-train seven staff scientists and junior faculty broadly to provide continuous and uninterrupted service 5) Renovate 5,000 sq. ft. of space to accommodate the specialized scientific instruments and personnel. By accomplishing these specific aims, we will centralize operations, increase efficiencies and create a more robust infrastructure for research services and training. This enhanced, unified strategic direction and execution will allow for uniformity, prioritizing future directions, and increased productivity by reducing redundancies in previously separate operations. The transformation of the space and cores into a more efficient and highly integrated research services suite will lower the startup cost burden of the newly recruited faculty while also providing excellent service value for our existing researchers.!

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54MD007586-32
Application #
9569285
Study Section
Special Emphasis Panel (ZMD1)
Project Start
Project End
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
32
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Meharry Medical College
Department
Type
DUNS #
041438185
City
Nashville
State
TN
Country
United States
Zip Code
37208
Ochieng, Josiah; Nangami, Gladys; Sakwe, Amos et al. (2018) Extracellular histones are the ligands for the uptake of exosomes and hydroxyapatite-nanoparticles by tumor cells via syndecan-4. FEBS Lett 592:3274-3285
Mishra, Abheepsa; Ayasolla, Kamesh; Kumar, Vinod et al. (2018) Modulation of apolipoprotein L1-microRNA-193a axis prevents podocyte dedifferentiation in high-glucose milieu. Am J Physiol Renal Physiol 314:F832-F843
Abney, Kristopher K; Ramos-Hunter, Susan J; Romaine, Ian M et al. (2018) Selective Activation of N,N'-Diacyl Rhodamine Pro-fluorophores Paired with Releasing Enzyme, Porcine Liver Esterase (PLE). Chemistry 24:8985-8988
Cook, Mekeila C; Barnert, Elizabeth; Ijadi-Maghsoodi, Roya et al. (2018) Exploring Mental Health and Substance use Treatment Needs of Commercially Sexually Exploited Youth Participating in a Specialty Juvenile Court. Behav Med 44:242-249
Ho, Meng-Hsuan; Lamont, Richard J; Chazin, Walter J et al. (2018) Characterization and development of SAPP as a specific peptidic inhibitor that targets Porphyromonas gingivalis. Mol Oral Microbiol 33:430-439
Cunningham-Erves, Jennifer L; Kelly-Taylor, Kendria D; Mayo-Gamble, Tilicia L et al. (2018) A Physician's Recommendation for Human Papillomavirus Vaccination: What Makes African-American Mothers Compliant? Pediatr Infect Dis J 37:e222-e225
Dash, Sabyasachi; Balasubramaniam, Muthukumar; Dash, Chandravanu et al. (2018) Biotin-based Pulldown Assay to Validate mRNA Targets of Cellular miRNAs. J Vis Exp :
Tang, Yuyang; George, Alvin M; Petrechko, Oksana et al. (2018) Pseudotyping of HIV-1 with Human T-Lymphotropic Virus 1 (HTLV-1) Envelope Glycoprotein during HIV-1-HTLV-1 Coinfection Facilitates Direct HIV-1 Infection of Female Genital Epithelial Cells: Implications for Sexual Transmission of HIV-1. mSphere 3:
Cunningham-Erves, Jennifer; Forbes, Laura; Ivankova, Nataliya et al. (2018) Black mother's intention to vaccinate daughters against HPV: A mixed methods approach to identify opportunities for targeted communication. Gynecol Oncol 149:506-512
Balasubramaniam, Muthukumar; Pandhare, Jui; Dash, Chandravanu (2018) Are microRNAs Important Players in HIV-1 Infection? An Update. Viruses 10:

Showing the most recent 10 out of 57 publications