The RCMI Program in Health Disparities Research at Meharry Medical College (RHDR@MMC) proposes to address health disparities at multiples scales of research: from micro to macro environments. With institutional collaboration and support, this application continues the long-term RCMI support of enabling high quality basic, behavioral, and clinical research to eliminate health disparities as our long-term goal. The RHDR@MMC is not discipline or disease focused, but emphasizes the disruption of disparity at all scales, from proteins to the human ecosystems of the populations we serve. Our re-envisioned Research Infrastructure Core will provide expert technical support in areas relevant to the research projects, as well as services such as design, biostatistics, bio and health informatics, and cross-training support to benefit ALL researchers at the institution. We have assembled a cadre of scientists including basic, behavioral, dental clinicians, population-based, and community-engaged researchers at Meharry to participate in this endeavor.
Our aims are to: 1. Support four outstanding research projects addressing HIV-AIDS, prostate cancer, racial and ethnic differences in periodontal disease microbiomes, and adversity-driven chronic pain to advance fundamental understanding of these health disparities. 2. Strengthen core technologies and expand bioinformatics and biostatistical services supporting the four research projects, as well as all Meharry research faculty, to increase institutional success in extramural funding studying diseases that disproportionally affect minority and other health disparity populations. 3. Nurture an environment conducive to developing new and early career investigators by facilitating a mentorship network, enhancing professional developmental activities, and providing pilot project funds. 4. Improve and expand relationships with community-based organizations that partner with Meharry. 5. Recruit outstanding magnet scientists to energize current faculty and contribute to our research capacity in cancers of the underserved, infectious diseases including HIV-AIDS, disparity-causing differences in microbiomes of minorities, and societal adversity leading to debilitating chronic pain in African Americans.

Public Health Relevance

The RCMI Program in Health Disparities Research is designed to address health disparities through research in diseases that affect the community it serves, engagement of this community in its solutions, and creating technologies and research infrastructure to serve the institutional scientific community and its academic and community partners. This collaborative approach is critical because finding the right answers to address disparities in health equity involves all of us.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54MD007586-34
Application #
9974573
Study Section
Special Emphasis Panel (ZMD1)
Program Officer
Das, Rina
Project Start
1997-09-30
Project End
2022-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
34
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Meharry Medical College
Department
Type
Graduate Schools
DUNS #
041438185
City
Nashville
State
TN
Country
United States
Zip Code
37208
Graves, Cornelia R; Davis, Stacy F (2018) Cardiovascular Complications in Pregnancy: It Is Time for Action. Circulation 137:1213-1215
Balasubramaniam, Muthukumar; Pandhare, Jui; Dash, Chandravanu (2018) Are microRNAs Important Players in HIV-1 Infection? An Update. Viruses 10:
Cheatham, Amber M; Davis, Shamara E; Khatua, Atanu K et al. (2018) Blocking the 5' splice site of exon 4 by a morpholino oligomer triggers APOL1 protein isoform switch. Sci Rep 8:8739
Dong, Xin-Hong; Ho, Meng-Hsuan; Liu, Bindong et al. (2018) Role of Porphyromonas gingivalis outer membrane vesicles in oral mucosal transmission of HIV. Sci Rep 8:8812
Santos-Barriopedro, Irene; Bosch-Presegué, Laia; Marazuela-Duque, Anna et al. (2018) SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-?B pathway. Nat Commun 9:101
Tantawy, Mohammed N; Charles Manning, H; Peterson, Todd E et al. (2018) Translocator Protein PET Imaging in a Preclinical Prostate Cancer Model. Mol Imaging Biol 20:200-204
Pajarillo, Edward; Johnson Jr, James; Kim, Judong et al. (2018) 17?-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity. Neurotoxicology 65:280-288
Suman, Shankar; Rachakonda, Girish; Mandape, Sammed N et al. (2018) Phospho-proteomic analysis of primary human colon epithelial cells during the early Trypanosoma cruzi infection phase. PLoS Negl Trop Dis 12:e0006792
Ignacio, Rosa Mistica C; Dong, Yuan-Lin; Kabir, Syeda M et al. (2018) CXCR2 is a negative regulator of p21 in p53-dependent and independent manner via Akt-mediated Mdm2 in ovarian cancer. Oncotarget 9:9751-9765
Miner, Martin; Parish, Sharon J; Billups, Kevin L et al. (2018) Erectile Dysfunction and Subclinical Cardiovascular Disease. Sex Med Rev :

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