The revised aims of this project are (1) To investigate the early course of development in children with autism, examining the influence of specific child, family, and intervention factors on stability and change in the core symptoms of autism (i.e., social impairment, communication, and repetitive behaviors/interests); and (2) To investigate the psychological well-being of mothers and fathers of children with autism during early childhood, examining relations between child, family, and intervention factors on stability and change in both positive and negative well-being. This work is based in a developmental contextual framework, in which child level processes are best understood within a complex context that includes parent and family processes and the interventions available to the child and family. We hypothesize that (1) The severity of core symptoms of autism are influenced directly by the presence of co-occurring problem behaviors, competencies and the intensity of intervention services, and indirectly by the child's predisposing temperament and parental well being. (2) Parental well-being is influenced directly by parental resources, family climate, severity of the broader autism phenotype, and the child's symptoms and problem behaviors. These variables also mediate the effects of other child factors and the parents' satisfaction with the intervention services received by their child. To test these hypotheses, we plan to recruit through early intervention specialty service programs 300 18-33 month-old children diagnosed with autism and to conduct a five-year, accelerated cross-sequential longitudinal study of their development and the changes that take place in the family and in the parents' well-being. We believe that the knowledge gained will inform developmental theory and will lead to the development of more effective and responsive child and parent support interventions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54MH066398-02
Application #
7560742
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2004-05-01
Budget End
2005-04-30
Support Year
2
Fiscal Year
2004
Total Cost
$187,100
Indirect Cost
Name
Boston University
Department
Type
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Mian, Nicholas D; Soto, Timothy W; Briggs-Gowan, Margaret J et al. (2018) The Family Life Impairment Scale: Factor Structure and Clinical Utility with Young Children. J Clin Child Adolesc Psychol :1-12
Giserman Kiss, Ivy; Feldman, Melanie S; Sheldrick, R Christopher et al. (2017) Developing Autism Screening Criteria for the Brief Infant Toddler Social Emotional Assessment (BITSEA). J Autism Dev Disord 47:1269-1277
Venker, Courtney E; Bolt, Daniel M; Meyer, Allison et al. (2015) Parent Telegraphic Speech Use and Spoken Language in Preschoolers With ASD. J Speech Lang Hear Res 58:1733-46
Green, Shulamite A; Carter, Alice S (2014) Predictors and course of daily living skills development in toddlers with autism spectrum disorders. J Autism Dev Disord 44:256-63
King, Bryan H; Dukes, Kimberly; Donnelly, Craig L et al. (2013) Baseline factors predicting placebo response to treatment in children and adolescents with autism spectrum disorders: a multisite randomized clinical trial. JAMA Pediatr 167:1045-52
Hallett, Victoria; Lecavalier, Luc; Sukhodolsky, Denis G et al. (2013) Exploring the manifestations of anxiety in children with autism spectrum disorders. J Autism Dev Disord 43:2341-52
Oblak, Adrian; Gibbs, Terrell T; Blatt, Gene J (2013) Reduced serotonin receptor subtypes in a limbic and a neocortical region in autism. Autism Res 6:571-83
Ben-Sasson, A; Soto, T W; Martínez-Pedraza, F et al. (2013) Early sensory over-responsivity in toddlers with autism spectrum disorders as a predictor of family impairment and parenting stress. J Child Psychol Psychiatry 54:846-53
Green, Shulamite A; Ben-Sasson, Ayelet; Soto, Timothy W et al. (2012) Anxiety and sensory over-responsivity in toddlers with autism spectrum disorders: bidirectional effects across time. J Autism Dev Disord 42:1112-9
Scahill, Lawrence; McCracken, James T; Bearss, Karen et al. (2012) Design and subject characteristics in the federally-funded citalopram trial in children with pervasive developmental disorders. J Autism Dev Disord 42:432-40

Showing the most recent 10 out of 38 publications