Our Center now has a broad range of experience in developing cell and bead based assaysfor the flow cytometer As summarized in target team progress report. We have 13 laboratory trained seniorstaff including 9PhDs, 3 MSs, and 1 BS. Eleven of these staff have experience in AD/A with flow cytometryand 11 of these staff have experience in HTS robotics including 2 who have worked with chemical libraries.Since HT multiplexing by flow cytometry was introduced to the scientific community by our Center via MLSCN,our team members have supported outreach to develop a target pipeline that can extend indefinitely into thefuture. Sklar, Prossnitz, and Edwards have given >60 outreach presentations to highlight Roadmap targets andopportunities. Nearly all of the assays involve collaborations between the target provider and our Center.Among the assays submitted so far, essentially all but the VLA-4 and Quorom Sensing assays required adevelopment phase.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54MH084690-01
Application #
7637659
Study Section
Special Emphasis Panel (ZRG1-IFCN-K (52))
Project Start
2008-09-01
Project End
2014-05-31
Budget Start
2008-07-01
Budget End
2009-05-31
Support Year
1
Fiscal Year
2008
Total Cost
$417,515
Indirect Cost
Name
University of New Mexico Health Sciences Center
Department
Type
DUNS #
829868723
City
Albuquerque
State
NM
Country
United States
Zip Code
87131
Palsuledesai, Charuta C; Surviladze, Zurab; Waller, Anna et al. (2018) Activation of Rho Family GTPases by Small Molecules. ACS Chem Biol 13:1514-1524
Bredemeyer, Andrea L; Edwards, Bruce S; Haynes, Mark K et al. (2018) High-Throughput Screening Approach for Identifying Compounds That Inhibit Nonhomologous End Joining. SLAS Discov 23:624-633
Wu, Yang; Stauffer, Shaun R; Stanfield, Robyn L et al. (2016) Discovery of Small-Molecule Nonfluorescent Inhibitors of Fluorogen-Fluorogen Activating Protein Binding Pair. J Biomol Screen 21:74-87
Yang, Jeremy J; Ursu, Oleg; Lipinski, Christopher A et al. (2016) Badapple: promiscuity patterns from noisy evidence. J Cheminform 8:29
Zahoránszky-K?halmi, Gergely; Bologa, Cristian G; Oprea, Tudor I (2016) Impact of similarity threshold on the topology of molecular similarity networks and clustering outcomes. J Cheminform 8:16
Hong, Lin; Chavez, Stephanie; Smagley, Yelena et al. (2016) Relationship of light scatter change and Cdc42-regulated actin status. Cytometry B Clin Cytom 90:499-505
Sykes, David B; Kfoury, Youmna S; Mercier, François E et al. (2016) Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell 167:171-186.e15
Holmes, Ann R; Cardno, Tony S; Strouse, J Jacob et al. (2016) Targeting efflux pumps to overcome antifungal drug resistance. Future Med Chem 8:1485-501
Magana, Maria; Ioannidis, Anastasios; Magiorkinis, Emmanouil et al. (2015) Therapeutic options and emerging alternatives for multidrug resistant staphylococcal infections. Curr Pharm Des 21:2058-72
Bologa, Cristian G; Ursu, Oleg; Halip, Liliana et al. (2015) CHEMICAL AND BIOLOGICAL DESCRIPTOR INTEGRATION IMPROVES COMPUTATIONAL MODELING OF IN VIVO RAT TOXICITY. Rev Roum Chim 60:219-226

Showing the most recent 10 out of 113 publications