Abstract

D3.2. MAINTAIN A ROBUST INFORMATICS ENVIRONMENT SUPPORTING JHICC ACTIVITIES The major responsible task of the Informatics Core is to handle the life cycle of an entire screening project from the beginning of assay transfer to the endpoint of PubChem update (and final data warehousing). Specific tasks include data acquisition and storage, data analyses and management, PubChem publishing and various distribution functions with NIH, collaborating centers and assay providers. Core Function 1. Register and update the NIH compound collection at JHICC site 2. Maintain a robust informatics environment supporting JHICC activities 3. Perform timely tasks of PubChem deposition

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54MH084691-04
Application #
8339198
Study Section
Special Emphasis Panel (ZRG1-IFCN-K (52))
Project Start
2008-09-01
Project End
2013-11-04
Budget Start
2011-06-01
Budget End
2013-05-31
Support Year
4
Fiscal Year
2011
Total Cost
$196,380
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Agoulnik, Alexander I; Agoulnik, Irina U; Hu, Xin et al. (2017) Synthetic non-peptide low molecular weight agonists of the relaxin receptor 1. Br J Pharmacol 174:977-989
Wu, Ying; Zou, Beiyan; Liang, Lingli et al. (2017) Loperamide inhibits sodium channels to alleviate inflammatory hyperalgesia. Neuropharmacology 117:282-291
Qu, Chunrong; Ding, Mingmin; Zhu, Yingmin et al. (2017) Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels. J Med Chem 60:4680-4692
Yu, Hai-bo; Zou, Bei-yan; Wang, Xiao-liang et al. (2016) Investigation of miscellaneous hERG inhibition in large diverse compound collection using automated patch-clamp assay. Acta Pharmacol Sin 37:111-23
Sun, Han; Luo, Liqun; Lal, Bachchu et al. (2016) A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis. Nat Commun 7:10339
Peters, Christian J; Yu, Haibo; Tien, Jason et al. (2015) Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels. Proc Natl Acad Sci U S A 112:3547-52
Zhang, Hongkang; Zou, Beiyan; Du, Fang et al. (2015) Reporting sodium channel activity using calcium flux: pharmacological promiscuity of cardiac Nav1.5. Mol Pharmacol 87:207-17
Wen, Wandong; Wang, Yan; Li, Zhe et al. (2015) Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1. ChemMedChem 10:57-61
Schreiber, Stuart L; Kotz, Joanne D; Li, Min et al. (2015) Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell 161:1252-65
Zhu, Yingmin; Lu, Yungang; Qu, Chunrong et al. (2015) Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br J Pharmacol 172:3495-509

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