Abstract

Core Functions: 1. Prepare compounds provided by the NIH 2. Maintain and reconfigure HTS facility with an optimal throughput 3. Perform HTS for different channel targets with either ICR12000 or FDSS-enabled formats 4. Produce data with high quality HTS criteria while containing costs 5. Perform initial validation and counter-screen 6. Perform secondary validation (via a subcontract with Aviva Biosciences) 7. Perform QA and QC.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54MH084691-04
Application #
8333174
Study Section
Special Emphasis Panel (ZRG1)
Project Start
2008-09-01
Project End
2013-11-04
Budget Start
2011-06-01
Budget End
2013-05-31
Support Year
4
Fiscal Year
2011
Total Cost
$2,108,474
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Agoulnik, Alexander I; Agoulnik, Irina U; Hu, Xin et al. (2017) Synthetic non-peptide low molecular weight agonists of the relaxin receptor 1. Br J Pharmacol 174:977-989
Wu, Ying; Zou, Beiyan; Liang, Lingli et al. (2017) Loperamide inhibits sodium channels to alleviate inflammatory hyperalgesia. Neuropharmacology 117:282-291
Qu, Chunrong; Ding, Mingmin; Zhu, Yingmin et al. (2017) Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels. J Med Chem 60:4680-4692
Yu, Hai-bo; Zou, Bei-yan; Wang, Xiao-liang et al. (2016) Investigation of miscellaneous hERG inhibition in large diverse compound collection using automated patch-clamp assay. Acta Pharmacol Sin 37:111-23
Sun, Han; Luo, Liqun; Lal, Bachchu et al. (2016) A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis. Nat Commun 7:10339
Schreiber, Stuart L; Kotz, Joanne D; Li, Min et al. (2015) Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell 161:1252-65
Zhu, Yingmin; Lu, Yungang; Qu, Chunrong et al. (2015) Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br J Pharmacol 172:3495-509
Li, Weiqiang; Koutmou, Kristin S; Leahy, Daniel J et al. (2015) Systemic RNA Interference Deficiency-1 (SID-1) Extracellular Domain Selectively Binds Long Double-stranded RNA and Is Required for RNA Transport by SID-1. J Biol Chem 290:18904-13
Yu, Haibo; Zou, Beiyan; Wang, Xiaoliang et al. (2015) Effect of tyrphostin AG879 on Kv 4.2 and Kv 4.3 potassium channels. Br J Pharmacol 172:3370-82
Du, Fang; Babcock, Joseph J; Yu, Haibo et al. (2015) Global analysis reveals families of chemical motifs enriched for HERG inhibitors. PLoS One 10:e0118324

Showing the most recent 10 out of 60 publications