Abstract

Since cembranoids are not commercially available, it is necessary to obtain them from their natural sources: soft corals found in the tropical seas around Puerto Rico, or from tobacco. The Natural Products Core is a unique CMBN facility that will became a part of the SNRP to provide the cembranoids needed in Projects 1 and 2. This core will organize diving expeditions for collections of specimens, will isolate the compounds to high purity, prepare custom-tailored synthetic analogues, determine their molecular structures, and calculates energy-minimized three-dimensional conformations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54NS039408-04
Application #
6666477
Study Section
Special Emphasis Panel (ZNS1)
Project Start
2002-09-01
Project End
2003-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
4
Fiscal Year
2002
Total Cost
$148,221
Indirect Cost

  Institution

Name
Universidad Central Del Caribe
Department
Type
DUNS #
City
Bayamon
State
PR
Country
United States
Zip Code
00960

  Publications

Budworth, Helen; Harris, Faye R; Williams, Paul et al. (2015) Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington's Disease. PLoS Genet 11:e1005267
Martins, Antonio H; Hu, Jing; Xu, Zhenfeng et al. (2015) Neuroprotective activity of (1S,2E,4R,6R,-7E,11E)-2,7,11-cembratriene-4,6-diol (4R) in vitro and in vivo in rodent models of brain ischemia. Neuroscience 291:250-259
Bykhovskaia, Maria; Jagota, Anand; Gonzalez, Agustin et al. (2013) Interaction of the complexin accessory helix with the C-terminus of the SNARE complex: molecular-dynamics model of the fusion clamp. Biophys J 105:679-90
Ferchmin, P A; Pérez, Dinely; Castro Alvarez, William et al. (2013) ?-Aminobutyric acid type A receptor inhibition triggers a nicotinic neuroprotective mechanism. J Neurosci Res 91:416-25
Torres-Rivera, W; Pérez, D; Park, K-Y et al. (2013) Kinin-B2 receptor exerted neuroprotection after diisopropylfluorophosphate-induced neuronal damage. Neuroscience 247:273-9
Eterovi?, Vesna A; Del Valle-Rodriguez, Angelie; Pérez, Dinely et al. (2013) Protective activity of (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol analogues against diisopropylfluorophosphate neurotoxicity: preliminary structure-activity relationship and pharmacophore modeling. Bioorg Med Chem 21:4678-86
Maldonado, Carolina; Alicea, Daniel; Gonzalez, Maryvi et al. (2013) Adar is essential for optimal presynaptic function. Mol Cell Neurosci 52:173-80
Rodriguez-Mercado, Rafael; Ford, Gregory D; Xu, Zhenfeng et al. (2012) Acute neuronal injury and blood genomic profiles in a nonhuman primate model for ischemic stroke. Comp Med 62:427-38
Martins, Antonio H; Alves, Janaina M; Perez, Dinely et al. (2012) Kinin-B2 receptor mediated neuroprotection after NMDA excitotoxicity is reversed in the presence of kinin-B1 receptor agonists. PLoS One 7:e30755
Long, Rong; Hui, Chung-Yuen; Jagota, Anand et al. (2012) Adhesion energy can regulate vesicle fusion and stabilize partially fused states. J R Soc Interface 9:1555-67

Showing the most recent 10 out of 54 publications